The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum

被引：35

作者：

Escalante, Ananias A. ^{[1
]}

Smith, David L. ^{[2
,3
]}

Kim, Yuseob ^{[1
]}

机构：

[1] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA

[2] Univ Florida, Dept Biol, Gainesville, FL 32611 USA

[3] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32611 USA

来源：

TRENDS IN PARASITOLOGY | 2009年 / 25卷 / 12期

基金：

美国国家科学基金会;

关键词：

SELECTIVE SWEEPS; PYRIMETHAMINE RESISTANCE; LINKAGE DISEQUILIBRIUM; CHLOROQUINE-RESISTANCE; MALARIA TRANSMISSION; PFCRT POLYMORPHISM; HITCHHIKING; EVOLUTION; ALLELES; POPULATION;

D O I：

10.1016/j.pt.2009.09.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat. Investigating the dynamics of resistance against these antimalarial drugs will lead to approaches for addressing the problem of resistance in malarial parasites that are solidly based in evolutionary genetics and population biology. In this article, we discuss current developments in population biology modeling and evolutionary genetics. Despite great advancements achieved in the past decade, understanding the complex dynamics of mutations conferring drug resistance in P. falciparum requires approaches that consider the parasite population structure among other demographic processes.

引用

页码：557 / 563

页数：7

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