The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p

被引：63
|
作者：
Jay, P
BergeLefranc, JL
Marsollier, C
Mejean, C
Taviaux, S
Berta, P
机构：
[1] CTR RECH BIOCHIM MACROMOL,CNRS ERS 155,INSERM U249,F-34033 MONTPELLIER,FRANCE
[2] FAC MED MARSEILLE,INSERM U406,F-13385 MARSEILLE,FRANCE
来源：
ONCOGENE | 1997年 / 14卷 / 14期
关键词：
CYR61; immediate early gene; CCN family; mosaic protein;
D O I：
10.1038/sj.onc.1200986
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.
引用
收藏
页码：1753 / 1757
页数：5
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