Stem Cell-Secreted Factors in the Tumor Microenvironment

被引：2
作者：
Jimenez, Gema [1 ,2 ,3 ]
Lopez de Andres, Julia [1 ,2 ,3 ]
Antonio Marchal, Juan [1 ,2 ,3 ,4 ]
机构：
[1] Univ Granada, Ctr Biomed Res CIBM, Biopathol & Regenerat Med Inst IBIMER, Granada, Spain
[2] Univ Granada, Univ Hosp Granada, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain
[3] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain
[4] Univ Granada, Fac Med, Dept Human Anat & Embryol, Granada, Spain
来源：
TUMOR MICROENVIRONMENT: MOLECULAR PLAYERS, PT B | 2020年 / 1277卷
关键词：
Cancer stem cells; Mesenchymal stem cells; Cancer-associated fibroblasts; Tumor microenvironment; Secretome; Growth factors; Cytokines; Extracellular matrix; Niche; Angiogenesis; Hypoxia; Metastasis; Epithelial-to-mesenchymal transition; Homing; Inflammation; MESENCHYMAL STROMAL CELLS; EXTRACELLULAR-MATRIX; MOLECULAR PATHWAYS; DRUG-RESISTANCE; BREAST-TUMORS; CANCER; FIBROBLASTS; GROWTH; ANGIOGENESIS; NICHE;
D O I：
10.1007/978-3-030-50224-9_8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The importance of the microenvironment in tumor development and their resistance to drugs is increasingly well known. This microenvironment is composed of different cell types, among which cells with stemness properties such as cancer stem cells (CSCs) and mesenchymal stem cells (MSCs) are distinguished for their relevant role in tumor proliferation, angiogenesis, metastasis, and drug resistance. The relationship between these stem cells (SCs) and tumor microenvironment is conducted by the secretome, consisting of several factors, cytokines, chemokines, and hormones released to the surrounding stroma, which plays a deterministic role in tumor hallmarks. Knowing the intrinsic and complex communication network that SCs establish with the microenvironment will allow to address the tumor processes responsible for cancer progression and the generation of new targeted therapeutic approaches useful in the clinic arena.
引用
收藏
页码：115 / 126
页数：12
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