Preparation of sub-2 μmlarge-pore monodispersed mesoporous silica spheres using mixed templates and application in HPLC

被引：12

作者：

Du, Yajun ^{[1
]}

Cheng, Lingping ^{[1
]}

Chen, Long ^{[1
]}

He, Yunchao ^{[1
]}

Wu, Yaling ^{[1
]}

He, Shanshan ^{[1
]}

Ke, Yanxiong ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2018年 / 265卷

关键词：

Monodispersed; Silica spheres; Large-pore; C18; HPLC; PERFORMANCE LIQUID-CHROMATOGRAPHY; BOVINE SERUM-ALBUMIN; MOLECULAR-SIEVES; TRIBLOCK-COPOLYMER; MORPHOLOGICAL CONTROL; CRYSTAL; SURFACTANT; SBA-15; MCM-41; FILMS;

D O I：

10.1016/j.micromeso.2017.02.051

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Sub-2 mu m large-pore monodispersed mesoporous silica spheres (MMSS) were synthesized by using mixed non-ionic surfactants of dodecylamine (DDA) and dodecylamine polyoxyethylene ether (AC1210) as templates through an alkali-catalyzed silica sol-gel technique combined with the template method. Methanol-H2O volume ratio on morphology was researched in detail. In addition, by using hydrothermal treatment, the average pore size of MMSS could be enlarged to 11 nm from 4.4 nm. The mesoporous silica particles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), laser particle size analyzer, X-ray diffraction, N-2 physisorption technique. The synthesized sub-2 mu m monodispersed mesoporous silica microspheres were successfully functionalized by dimethyloctadecylchlorosilane and used as a packing material in high performance liquid chromatography (HPLC). (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：234 / 240

页数：7

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