CD28 gene polymorphisms and acute cellular rejection after liver transplantation

被引：1

作者：

Thude, Hansjoerg ^{[1
]}

Tiede, Petra ^{[1
]}

Sterneck, Martina ^{[2
]}

Peine, Sven ^{[1
]}

Nashan, Bjoern ^{[3
,4
]}

Koch, Martina ^{[3
,5
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Transfus Med, Martinistr 52, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Transplantat Ctr, Martinistr 52, D-20246 Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Hepatobiliary & Transplant Surg, Martinistr 52, D-20246 Hamburg, Germany

[4] Univ Sci & Technol China, Affiliated Hosp 1, Hefei, Anhui, Peoples R China

[5] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Gen Visceral & Abdominal Surg, Langenbeckstr 1, D-55131 Mainz, Germany

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 12期

关键词：

Acute cellular liver transplant rejection; CD28; Gene polymorphisms; Liver transplantation; SOLUBLE CD28; ASSOCIATION; CTLA-4; SUSCEPTIBILITY; EXPRESSION; IMPACT;

D O I：

10.1016/j.humimm.2020.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective casecontrol study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associated with acute cellular liver transplant rejection. The mentioned SNPs were genotyped in 147 liver transplant recipients without acute cellular rejection and 144 liver transplant recipients with acute cellular rejection by realtime endpoint genotyping. The genotype and allele frequencies of the SNPs did not show any significant differences between both groups. Haplotype analyzes of the SNPs also showed no association. Ou r data suggest that the analyzed SNPs are not major contributors to the susceptibility of acute cellular liver transplant rejection.

引用

页码：675 / 678

页数：4

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