Effect of tissue factor deficiency on mouse and tumor development

被引：77

作者：

Toomey, JR ^{[1
]}

Kratzer, KE ^{[1
]}

Lasky, NM ^{[1
]}

Broze, GJ ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, BARNES JEWISH HOSP, DIV HEMATOL, ST LOUIS, MO 63110 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 13期

关键词：

D O I：

10.1073/pnas.94.13.6922

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous reports suggest that tissue factor (TF) may play an essential role in embryonic vascular development and tumor angiogenesis. To further examine this relationship, the morphology of fully developed TF-deficient embryos and the growth of TF-deficient teratomas and teratocarcinomas were analyzed. In a 129/Sv genetic background, TF null embryos do not survive beyond mid-gestation, In contrast, 14% of 129/Sv x C57BL/6 TF-deficient embryos escape this early mortality and survive to birth, On gross and microscopic inspection, these late gestation, TP-deficient embryos appear normal., The growth and vascularity of TF(+/+), TF(+/-), and TP(-/-) teratomas and teratocarcinomas are indistinguishable, Thus, tumor-derived TF is not required for tumor growth and angiogenesis and the combined data do not support an essential role for TF in embryonic vascular development.

引用

页码：6922 / 6926

页数：5

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