Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma

被引：4

作者：

Mori, Akio ^{[1
]}

Ueno, Yuji ^{[1
]}

Kuroki, Takuma ^{[1
]}

Hoshino, Yasunobu ^{[1
]}

Shimura, Hideki ^{[1
]}

Sekiguchi, Yasunobu ^{[2
]}

Noguchi, Masaaki ^{[2
]}

Hamada, Yukihiro ^{[3
]}

Kusunoki, Susumu ^{[3
]}

Hattori, Nobutaka ^{[4
]}

Urabe, Takao ^{[1
]}

机构：

[1] Juntendo Univ, Dept Neurol, Urayasu Hosp, Urayasu, Chiba 2790021, Japan

[2] Juntendo Univ, Dept Hematol, Urayasu Hosp, Urayasu, Chiba 2790021, Japan

[3] Kinki Univ Hosp, Dept Neurol, Higashiosaka, Osaka, Japan

[4] Juntendo Univ, Sch Med, Dept Neurol, Urayasu, Chiba 2790021, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2014年 / 337卷 / 1-2期

关键词：

Anti-ganglioside antibody; Anti-disialosyl antibody; Motor-dominant neuropathy; Mantle cell lymphoma; Sensory-motor neuropathy; Plasma exchange; PERIPHERAL NERVOUS-SYSTEM; SENSORY ATAXIC NEUROPATHY; GD1B; GM1; POLYRADICULONEUROPATHY; RESIDUE;

D O I：

10.1016/j.jns.2013.11.026

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A rapidly progressive motor-dominant neuropathy associated with IgM monoclonal antibody against ganglio-sides with disialosyl residues, GD3, GD1b, GT1b, and GQ1b, in a 60-year-old Japanese man with mantle cell lymphoma is reported. Plasma exchange. and chemotherapy for mantle cell lymphoma were performed for the neuropathy and mantle cell lymphoma. After therapy, the motor neuropathy dramatically improved concurrently with substantial reduction of the antibody activities especially in reaction to GD1b. This is the first case report of neuropathy with anti-disialosyl IgM antibodies associated with mantle cell lymphoma, and plasma exchange and chemotherapy were effective. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：215 / 218

页数：4

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