Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams

被引：34

作者：

Companyo, Xavier ^{[1
]}

Geant, Pierre-Yves ^{[3
]}

Mazzanti, Andrea ^{[2
]}

Moyano, Albert ^{[1
]}

Rios, Ramon ^{[1
,3
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Catalonia, Spain

[2] Univ Bologna, Sch Sci, Dept Ind Chem Toso Montanari, I-40136 Bologna, Italy

[3] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON | 2014年 / 70卷 / 01期

关键词：

Organocatalysis; Lactams; Asymmetric synthesis; One-pot reaction; Morita-Baylis-Hillman; BAYLIS-HILLMAN CARBONATES; STEREOCONTROLLED SYNTHESIS; SESQUITERPENE LACTONES; HELENALIN; CONSTRUCTION; CYCLIZATION; ESTERS; ROUTE;

D O I：

10.1016/j.tet.2013.11.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An organocatalytic enantioselective synthesis of alpha-methylene-gamma-lactams has been developed. The reaction between protected 2-aminomalonates and Morita-Baylis-Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：75 / 82

页数：8

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