Suppression of TNFα expression induced by indole-3-acetic acid is not mediated by AhR activation in Caco-2 cells

被引：8

作者：

Chowdhury, Md Mazharul Islam ^{[1
]}

Kurata, Koichi ^{[2
]}

Yuasa, Kana ^{[3
]}

Koto, Yoshihito ^{[3
]}

Nishimura, Kohji ^{[1
,2
,3
,4
,5
,6
]}

Shimizu, Hidehisa ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Tottori Univ, United Grad Sch Agr Sci, Tottori, Tottori, Japan

[2] Shimane Univ, Grad Sch Life & Environm Sci, Matsue, Shimane, Japan

[3] Shimane Univ, Grad Sch Nat Sci & Technol, Matsue, Shimane, Japan

[4] Shimane Univ, Raman Project Ctr Med & Biol Applicat, Matsue, Shimane, Japan

[5] Shimane Univ, Interdisciplinary Ctr Sci Res, Matsue, Shimane, Japan

[6] Shimane Univ, Acad Assembly, Inst Agr & Life Sci, Matsue, Shimane, Japan

[7] Shimane Univ, Estuary Res Ctr, Matsue, Shimane, Japan

[8] Shimane Univ, Project Ctr Fortificat Local Specialty Food Funct, Matsue, Shimane, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2021年 / 85卷 / 04期

关键词：

tumor necrosis factor alpha; inflammation; aryl hydrocarbon receptor; colorectal cancer; cytochrome P450 1A1; NF-KAPPA-B; REGULATES RENAL EXPRESSION; FIBROTIC GENE-EXPRESSION; GUT MICROBIOTA; INDOXYL; RECEPTOR; ROS; TRYPTOPHAN; P53; PROLIFERATION;

D O I：

10.1093/bbb/zbaa101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Indole-3-acetic acid (IAA) produced by intestinal bacteria from tryptophan in dietary proteins is considered to suppress the inflammatory response through aryl hydrocarbon receptor (AhR) activation. However, AhR activation was not involved in the downregulation of tumor necrosis factor alpha (TNF alpha) expression induced by IAA in Caco-2 cells. The activation of unidentified IAA receptors might attenuate the inflammatory response to TNF alpha in colorectal cancer cells.

引用

页码：902 / 906

页数：5

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