Novel biomimetic polymeric micelles for drug delivery

被引：0

作者：

Xu Jian-Ping ^{[1
]}

Chen Wei-Dong ^{[1
]}

Ji Jian ^{[1
]}

Shen Jia-Cong ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Minist Educ, Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2007年 / 28卷 / 02期

关键词：

polymeric micelles; biomimetic of cell membrane; drug sustained release; biocompatibility; phosphorylcholine;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel amphiphilic polymers, cholesterol-end-capped poly (2-methacryloyloxyethyl phosphorylcholine) (CMPC) was specially designed as the drug delivery systems. Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture. Anti-cancer drug adriamycin (ADR) was incorporated into the micelles by oil-in-water method. The release of ADR from the nanosphere continued over 7 d. The drug-loaded micelles could effectively restrain the growth of cancer cell. These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.

引用

页码：394 / 396

页数：3

共 9 条

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