Risk of Dementia in Adults With ADHD: A Nationwide, Population-Based Cohort Study in Taiwan

被引：40

作者：

Tzeng, Nian-Sheng ^{[1
,2
]}

Chung, Chi-Hsiang ^{[3
,4
,5
]}

Lin, Fu-Huang ^{[3
]}

Yeh, Chin-Bin ^{[1
]}

Huang, San-Yuan ^{[1
]}

Lu, Ru-Band ^{[1
,6
]}

Chang, Hsin-An ^{[1
,2
]}

Kao, Yu-Chen ^{[1
,7
]}

Yeh, Hui-Wen ^{[1
,8
,9
]}

Chiang, Wei-Shan ^{[1
,10
]}

Chou, Yu-Ching ^{[3
]}

Tsao, Chang-Huei ^{[4
,11
]}

Wu, Yung-Fu ^{[4
]}

Chien, Wu-Chien ^{[3
,4
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Sch Med, Dept Psychiat, Taipei, Taiwan

[2] Natl Def Med Ctr, Student Counseling Ctr, Taipei, Taiwan

[3] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[4] Triserv Gen Hosp, Sch Med, Dept Med Res, Natl Def Med Ctr, Taipei, Taiwan

[5] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei, Taiwan

[6] Natl Cheng Kung Univ, Dept Psychiat, Coll Med & Hosp, Tainan, Taiwan

[7] Triserv Gen Hosp, Natl Def Med Ctr, Song Shan Branch, Dept Psychiat, Taipei, Taiwan

[8] Natl Chiao Tung Univ, Inst Bioinformat & Syst Biol, Hsinchu, Taiwan

[9] Kang Ning Univ, Dept Nursing, Taipei Campus, Taipei, Taiwan

[10] Tamkang Univ, Dept & Inst Math, New Taipei, Taiwan

[11] Natl Def Med Ctr, Dept & Inst Microbiol & Immunol, Sch Med, Taipei, Taiwan

来源：

JOURNAL OF ATTENTION DISORDERS | 2019年 / 23卷 / 09期

关键词：

adults; ADHD adults; cohort study; dementia; National Health Insurance Research Database; Longitudinal Health Insurance Database; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; TRAUMATIC BRAIN-INJURY; DSM-IV; PREDICTIVE-VALIDITY; BIPOLAR DISORDER; HEALTH INSURANCE; MEDICATION; CHILDREN; ADOLESCENTS;

D O I：

10.1177/1087054717714057

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Objective:This study aimed to investigate the association between adults with ADHD and the risk of developing dementia. Method: Utilizing National Health Insurance Research Database of Taiwan, ADHD patients were identified and compared with age- and gender-matched controls (1:3). Results: Of the study participants, 37 (5.48%) developed dementia compared with 81 (4.0%) in the control group. Cox proportional hazards regression analysis revealed that the study participants were more likely to develop dementia. The crude hazard ratio (HR) is 3.418 (95% confidence interval [CI] = [2.289, 5.106], p < .001), and adjusted HR is 4.008 (95% CI = [2.526, 6.361], p < .001) in risk of developing dementia after adjusted for age, gender, comorbidities, geographical area of residence, urbanization level of residence, and monthly income. Conclusion: Adults with ADHD have a 3.4-fold risk of developing dementia, and other large or national data sets should be explored to support the current findings.

引用

页码：995 / 1006

页数：12

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