Klinefelter's syndrome (karyotype 47,XXY) and schizophrenia-spectrum pathology

被引：69
作者：
Van Rijn, Sophie
Aleman, Andre
Swaab, Hanna
Kahn, Rene S.
机构：
[1] Univ Utrecht, Inst Helminthol, NL-3508 TC Utrecht, Netherlands
[2] Univ Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, Med Ctr, NL-3508 TC Utrecht, Netherlands
[3] Univ Groningen, BCN Neuroimaging Ctr, NL-9700 AB Groningen, Netherlands
[4] Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3508 TA Utrecht, Netherlands
[5] Leiden Univ, Dept Clin Child & Adolescent Studies, NL-2300 RA Leiden, Netherlands
[6] Univ Utrecht, Med Ctr, Dept Psychiat, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands
来源：
BRITISH JOURNAL OF PSYCHIATRY | 2006年 / 189卷
关键词：
D O I：
10.1192/bjp.bp.105.008961
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Klinefelter's syndrome, characterised by a 47,XXYchromosomal pattern, has largely been associated with physical abnormalities. Here, we report high levels of schizophrenia-spectrum pathology in 32 men with this syndrome in comparison with 26 healthy controls. This may have implications for treatment of Klinefelter's syndrome and suggests that the X chromosome may be involved in the aetiology of schizophrenia.
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收藏
页码：459 / 460
页数：2
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