Photo-polymerizable ferrous sulfate liposomes as vehicles for iron fortification of food

被引:16
作者
Cheng, Jin [1 ]
Kenaan, Ahmad [1 ]
Zhao, Di [1 ]
Qi, Daizong [1 ]
Song, Jie [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Inst Nano Biomed & Engn,Dept Instrument Sci & Eng, Shanghai Engn Res Ctr Intelligent Diag & Treatmen, Shanghai, Peoples R China
基金
上海市自然科学基金; 中国国家自然科学基金;
关键词
Iron deficiency; Food fortification; Liposomes; Oxidation; IN-VITRO; DEFICIENCY; NANOLIPOSOMES;
D O I
10.1016/j.nano.2020.102286
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The development of photo-polymerizable ferrous sulfate liposomes has been perused for iron fortification of food. Iron fortification is accompanied by several limitations that reduce its quality as it provokes sensory problems due to the oxidation of Fe2+ into Fe3+. To overcome such undesirable effects and improve the bioavailability of iron, photo-polymerizable 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC8,9PC) phospholipids have been employed as iron delivery system. DC8,9PC possesses diacetylene groups that undergo intramolecular cross-linking following UV treatment, resulting in enhanced stability, high encapsulation efficiency (similar to 91%) without inducing sensory changes during milk fortification, along with less oxidation and con-tent leakage after long term storage in ethanol. Furthermore, polymeric Fe-DC8,9PC liposomes present high in vivo iron bioavailability in hemoglobin (Hb)-repletion study in rats, with no indications of toxicity examined by hematoxylin-eosin test. This methodology offers great promise for a simple, reliable, cost-effective, and robust platform for treating iron deficiency anemia, seeking to bring its application toward market. (C) 2020 Elsevier Inc. All rights reserved.
引用
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页数:9
相关论文
共 32 条
  • [1] Abbaspour N, 2014, J RES MED SCI, V19, P164
  • [2] [Anonymous], [No title captured]
  • [3] [Anonymous], [No title captured]
  • [4] Iron fortification and iron supplementation are cost-effective interventions to reduce iron deficiency in four subregions of the world
    Baltussen, R
    Knai, C
    Sharan, M
    [J]. JOURNAL OF NUTRITION, 2004, 134 (10) : 2678 - 2684
  • [5] Treatment of iron deficiency anemia associated with gastrointestinal tract diseases
    Bayraktar, Ulas D.
    Bayraktar, Soley
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (22) : 2720 - 2725
  • [6] Iron biology in immune function, muscle metabolism and neuronal functioning
    Beard, JL
    [J]. JOURNAL OF NUTRITION, 2001, 131 (02) : 568S - 579S
  • [7] Oxygen absorbers in food preservation: a review
    Cichello, Simon Angelo
    [J]. JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2015, 52 (04): : 1889 - 1895
  • [8] Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting
    Colas, Jean-Christophe
    Shi, Wanlong
    Rao, V. S. N. Malleswara
    Omri, Abdelwahab
    Mozafari, M. Reza
    Singh, Harjinder
    [J]. MICRON, 2007, 38 (08) : 841 - 847
  • [9] Nanotechnology: A Valuable Strategy to Improve Bacteriocin Formulations
    Fahim, Hazem A.
    Khairalla, Ahmed S.
    El-Gendy, Ahmed O.
    [J]. FRONTIERS IN MICROBIOLOGY, 2016, 7
  • [10] COMPARISON OF INVITRO, ANIMAL, AND CLINICAL DETERMINATIONS OF IRON BIOAVAILABILITY - INTERNATIONAL-NUTRITIONAL-ANEMIA CONSULTATIVE-GROUP-TASK-FORCE REPORT ON IRON BIOAVAILABILITY
    FORBES, AL
    ADAMS, CE
    ARNAUD, MJ
    CHICHESTER, CO
    COOK, JD
    HARRISON, BN
    HURRELL, RF
    KAHN, SG
    MORRIS, ER
    TANNER, JT
    WHITTAKER, P
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1989, 49 (02) : 225 - 238