Diagnostic precision of image-guided multisampling core needle biopsy of suspected lymphomas in a primary care hospital

被引:33
作者
Loubeyre, P. [1 ]
McKee, T. A. [2 ]
Copercini, M. [1 ]
Rosset, A. [1 ]
Dietrich, P-Y [3 ]
机构
[1] Univ Hosp Geneva, Dept Imaging & Med Informat, Div Radiol, CH-1211 Geneva 14, Switzerland
[2] Univ Hosp Geneva, Dept Med Genet & Lab Med, Div Clin Pathol, CH-1211 Geneva, Switzerland
[3] Univ Hosp Geneva, Dept Internal Med, Div Oncol Serv, CH-1211 Geneva 14, Switzerland
关键词
core needle biopsy; lymphoma; molecular analysis; ESMO CLINICAL RECOMMENDATIONS; CUTTING-EDGE-NEEDLE; MALIGNANT-LYMPHOMA; FOLLOW-UP; HODGKINS-LYMPHOMA; NODES; UTILITY;
D O I
10.1038/sj.bjc.6605059
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We evaluated the diagnostic quality of image-guided multisampling core needle biopsy (CNB) in patients investigated for suspected lymphoma in a primary care hospital. A total of 112 patients were consecutively assessed during a 3-year period. There were 80 lymphoid site biopsies and 32 non-lymphoid site biopsies. Eight to nine cores were obtained from different parts of the biopsy site. Two cores were systematically frozen, allowing for further morphological, immunochemistry and molecular studies. The diagnostic yield of CNB for malignancy was 100%. Only 47% (41/87) of patients with initial suspicion of lymphoma were finally diagnosed with Lymphoma. The diagnostic yield of CNB for lymphoma typing was 98% (62/63), according to the WHO classification. The diagnostic yield of CNB for complete lymphoma subtyping/grading was 86% (54/63). The diagnostic yield of CNB for a definite diagnosis of benignity was only 47% (8/17). In a primary care setting, multisampling CNB is a minimally invasive, and very accurate procedure for confirming malignancy in patients with suspected lymphoma, presenting with superficial/deep-seated, lymphoid/non-lymphoid site targets. With a very high diagnostic yield for lymphoma typing and a high diagnostic yield for complete lymphoma subtyping/grading a therapeutic decision can be taken in most patients. British Journal of Cancer (2009) 100, 1771-1776. doi: 10.1038/sj.bjc.6605059 www.bjcancer.com Published online 28 April 2009 (C) 2009 Cancer Research UK
引用
收藏
页码:1771 / 1776
页数:6
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