Effects of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats

被引：9

作者：

Inoue, Takayuki ^{[1
,2
]}

Hashimoto, Michio ^{[1
]}

Katakura, Masanori ^{[1
]}

Tanabe, Yoko ^{[1
]}

Al Mamun, Abdullah ^{[1
]}

Matsuzaki, Kentaro ^{[1
]}

Otani, Hiroki ^{[2
]}

Shido, Osamu ^{[1
]}

机构：

[1] Shimane Univ, Fac Med, Dept Environm Physiol, Izumo, Shimane 6938501, Japan

[2] Shimane Univ, Fac Med, Dept Dev Biol, Izumo, Shimane 6938501, Japan

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2014年 / 91卷 / 04期

关键词：

n-6 fatty acid; Oxidative stress; Aging; Skeletal muscles; Myosin heavy chain; MYOSIN HEAVY-CHAIN; DOCOSAHEXAENOIC ACID; FATTY-ACIDS; RESISTANCE EXERCISE; FIBER-TYPE; SARCOPLASMIC-RETICULUM; OXIDATIVE STRESS; LINOLEIC-ACID; PROTEIN; CONTRACTILE;

D O I：

10.1016/j.plefa.2014.07.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arachidonic acid (20:4n-6, ARA) is a major component of the cell membrane, whereas ARA-derived eicosanoids are formed when cells are damaged. Aging is associated with an accretion of oxidative stress in skeletal muscles. In this study, we examined the effects of chronic administration (13 weeks) of ARA (240 mg/kg/day) on fatty acid composition, antioxidative status, and morphology of slow (soleus muscles) and fast (extensor digitorum longus muscles; EDL)-twitch muscles in aged rats (21 months old). The level of reactive oxygen species was higher in the EDL of ARA-administered rats than in that of control rats. ARA administration decreased the muscle cell volumes and increased the number of slow myosin heavy chain (MHC)-positive cells in the EDL. The relative content of MHC2X was increased whereas the relative content of MHC2B was decreased in the EDL of ARA-administered rats. These results suggest that ARA deposition in the fast-twitch muscle of aged rats reduced cell volume with an increase in oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：119 / 127

页数：9

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