Tumor Suppressive Role of the PRELP Gene in Ovarian Clear Cell Carcinoma

被引：11

作者：

Dozen, Ai ^{[1
,2
]}

Shozu, Kanto ^{[1
,3
]}

Shinkai, Norio ^{[1
,4
,5
]}

Ikawa, Noriko ^{[1
]}

Aoyama, Rina ^{[1
,6
]}

Machino, Hidenori ^{[1
,4
]}

Asada, Ken ^{[1
,4
]}

Yoshida, Hiroshi ^{[7
]}

Kato, Tomoyasu ^{[8
]}

Hamamoto, Ryuji ^{[1
,4
,5
]}

Kaneko, Syuzo ^{[1
]}

Komatsu, Masaaki ^{[4
]}

机构：

[1] Natl Canc Ctr, Div Med AI Res & Dev, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan

[2] Keio Univ, Dept Obstet & Gynecol, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

[3] Univ Toyama, Dept Obstet & Gynecol, 2630 Sugitani, Toyama 9300194, Japan

[4] RIKEN Ctr Adv Intelligence Project, Canc Translat Res Team, Chuo Ku, 1-4-1 Nihonbashi, Tokyo 1030027, Japan

[5] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept NCC Canc Sci, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan

[6] Showa Univ, Dept Obstet & Gynecol, Sch Med, Shinagawa Ku, Tokyo 1428666, Japan

[7] Natl Canc Ctr, Dept Diagnost Pathol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan

[8] Natl Canc Ctr, Dept Gynecol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 12期

关键词：

ovarian clear cell carcinoma; PRELP; gene expression; epigenetics; PROGNOSTIC VALUE; ENDOMETRIOSIS; EXPRESSION; INHIBITORS; CANCER; PROTEOGLYCAN; EPIDEMIOLOGY; MUTATIONS; GENOME; PIK3CA;

D O I：

10.3390/jpm12121999

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Ovarian clear cell carcinoma (OCCC) has a poor prognosis, and its therapeutic strategy has not been established. PRELP is a leucine-rich repeat protein in the extracellular matrix of connective tissues. Although PRELP anchors the basement membrane to the connective tissue and is absent in most epithelial cancers, much remains unknown regarding its function as a regulator of ligand-mediated signaling pathways. Here, we obtained sets of differentially expressed genes by PRELP expression using OCCC cell lines. We found that more than 1000 genes were significantly altered by PRELP expression, particularly affecting the expression of a group of genes involved in the PI3K-AKT signaling pathway. Furthermore, we revealed the loss of active histone marks on the loci of the PRELP gene in patients with OCCC and how its forced expression inhibited cell proliferation. These findings suggest that PRELP is not only a molecule anchored in connective tissues but is also a signaling molecule acting in a tumor-suppressive manner. It can serve as the basis for early detection and novel therapeutic approaches for OCCC toward precision medicine.

引用

页数：14

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