Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Anethole Trithione by Combined Use of Surfactants

被引：7

作者：

Ren, Fuzheng ^{[1
]}

Jing, Qiufang ^{[1
]}

Cui, Jingbin ^{[1
]}

Chen, Jianming ^{[2
]}

Shen, Yongjia ^{[3
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Engn, Shanghai 200237, Peoples R China

[2] Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China

[3] E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2009年 / 30卷 / 05期

关键词：

Anethole trithione; dissolution; self-nanoemulsifying drug delivery system; surfactant; ENHANCED ORAL ABSORPTION; PHYSICOCHEMICAL PROPERTIES; STERIC STABILIZATION; NONIONIC SURFACTANT; FORMULATION DESIGN; IMPROVEMENT; BIOAVAILABILITY; MICROEMULSION; DISSOLUTION; OIL;

D O I：

10.1080/01932690802598960

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The characteristics of self-nanoemulsifying drug delivery system (SNEDDS) of Anethole trithione (ATT) for oral administration by the combined use of surfactants were investigated. In combination with surfactants, the SNEDDS provided smaller particle size, more oil loading, and shorter emulsification time. ATT from the SNEDDS rapidly dissolved in dissolution media whereas the ATT tablets showed different dissolution patterns according to the dissolution media. Furthermore, loading of ATT in SNEDDS improved the stability of ATT, and particle size of ATT nanoemulsion generated upon dilution was kept constant both in simulated gastric fluid and simulated intestinal fluid without enzyme.

引用

页码：664 / 670

页数：7

共 27 条

[1] A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs [J].

Bagheri, H ;

Schmitt, L ;

Berlan, M ;

Montastruc, JL .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1997, 52 (05) :339-342

[2] Correlations between n-octanol/water partition coefficients and RP-HPLC capacity factors of 1,2-dithiole-3-thiones and 1,2-dithiol-3-ones [J].

Boudeville, P ;

Bona, M ;

Burgot, JL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (09) :990-998

[3] SELF-EMULSIFYING DRUG DELIVERY SYSTEMS - FORMULATION AND BIOPHARMACEUTIC EVALUATION OF AN INVESTIGATIONAL LIPOPHILIC COMPOUND [J].

CHARMAN, SA ;

CHARMAN, WN ;

ROGGE, MC ;

WILSON, TD ;

DUTKO, FJ ;

POUTON, CW .

PHARMACEUTICAL RESEARCH, 1992, 9 (01) :87-93

[4]

CHIBA Y, 1991, CHEM PHARM BULL, V39, P2158, DOI 10.1248/cpb.39.2158

[5] Improvement in solubility and dissolution rate of 1,2-dithiole-3-thiones upon complexation with β-cyclodextrin and its hydroxypropyl and sulfobutyl ether-7 derivatives [J].

Dollo, G ;

Le Corre, P ;

Chollet, M ;

Chevanne, F ;

Bertault, M ;

Burgot, JL ;

Le Verge, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (09) :889-895

[6] Morphological observations on a lipid-based drug delivery system during in vitro digestion [J].

Fatouros, Dimitrios G. ;

Bergenstahl, Bjorn ;

Mullertz, Anette .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 31 (02) :85-94

[7] Treatment of xerostomia with the bile secretion-stimulating drug anethole trithione: A clinical trial [J].

Hamada, T ;

Nakane, T ;

Kimura, T ;

Arisawa, K ;

Yoneda, K ;

Yamamoto, T ;

Osaki, T .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1999, 318 (03) :146-151

[8] A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption [J].

Hong, JY ;

Kim, JK ;

Song, YK ;

Park, JS ;

Kim, CK .

JOURNAL OF CONTROLLED RELEASE, 2006, 110 (02) :332-338

[9] Evidence for synergism in nonionic surfactant mixtures: Enhancement of solubilization in water-in-oil microemulsions [J].

Huibers, PDT ;

Shah, DO .

LANGMUIR, 1997, 13 (21) :5762-5765

[10] Improvement of physicochemical properties of N-4472 part I formulation design by using self-micro emulsifying system [J].

Itoh, K ;

Tozuka, Y ;

Oguchi, T ;

Yamamoto, K .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 238 (1-2) :153-160

← 1 2 3 →