A brief history of RNAi: the silence of the genes

被引：149
作者：
Sen, George L.
Blau, Helen M.
机构：
[1] Stanford Univ, Sch Med, Baxter Lab Genet Pharmacol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA
来源：
FASEB JOURNAL | 2006年 / 20卷 / 09期
关键词：
Si RNA; shRNA; gene regulation; post-transitional gene silencing; dsRNA; mRNA degradation; mRNA decay centers; argonaute; p-bodies;
D O I：
10.1096/fj.06-6014rev
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.
引用
收藏
页码：1293 / 1299
页数：7
相关论文
共 59 条
[1]   The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex [J].
Anderson, JSJ ;
Parker, R .
EMBO JOURNAL, 1998, 17 (05) :1497-1506
[2]  
[Anonymous], NAT CELL BIOL
[3]   Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes [J].
Ashrafi, K ;
Chang, FY ;
Watts, JL ;
Fraser, AG ;
Kamath, RS ;
Ahringer, J ;
Ruvkun, G .
NATURE, 2003, 421 (6920) :268-272
[4]   A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates [J].
Bashkirov, VI ;
Scherthan, H ;
Solinger, JA ;
Buerstedde, JM ;
Heyer, WD .
JOURNAL OF CELL BIOLOGY, 1997, 136 (04) :761-773
[5]   A large-scale RNAi screen in human cells identifies new components of the p53 pathway [J].
Berns, K ;
Hijmans, EM ;
Mullenders, J ;
Brummelkamp, TR ;
Velds, A ;
Heimerikx, M ;
Kerkhoven, RM ;
Madiredjo, M ;
Nijkamp, W ;
Weigelt, B ;
Agami, R ;
Ge, W ;
Cavet, G ;
Linsley, PS ;
Beijersbergen, RL ;
Bernards, R .
NATURE, 2004, 428 (6981) :431-437
[6]   Role for a bidentate ribonuclease in the initiation step of RNA interference [J].
Bernstein, E ;
Caudy, AA ;
Hammond, SM ;
Hannon, GJ .
NATURE, 2001, 409 (6818) :363-366
[7]   Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines [J].
Billy, E ;
Brondani, V ;
Zhang, HD ;
Müller, U ;
Filipowicz, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14428-14433
[8]   The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis [J].
Carmell, MA ;
Xuan, ZY ;
Zhang, MQ ;
Hannon, GJ .
GENES & DEVELOPMENT, 2002, 16 (21) :2733-2742
[9]   TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [J].
Chendrimada, TP ;
Gregory, RI ;
Kumaraswamy, E ;
Norman, J ;
Cooch, N ;
Nishikura, K ;
Shiekhattar, R .
NATURE, 2005, 436 (7051) :740-744
[10]   Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa [J].
Cogoni, C ;
Macino, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10233-10238
123456