Polyelectrolyte-Coated Unilamellar Nanometer-Sized Magnetic Liposomes

被引：33

作者：

Gomes, Joana Filipa Pereira da Silva ^{[1
]}

Rank, Anja ^{[2
]}

Kronenberger, Astrid ^{[1
]}

Fritz, Juergen ^{[1
]}

Winterhalter, Mathias ^{[1
]}

Ramaye, Yannic ^{[1
]}

机构：

[1] Jacobs Univ Bremen, D-28725 Bremen, Germany

[2] Univ Freiburg, Dept Pharmaceut Technol & Biopharm, Inst Pharmaceut Sci, D-79104 Freiburg, Germany

来源：

LANGMUIR | 2009年 / 25卷 / 12期

关键词：

DRUG-DELIVERY SYSTEMS; GENE DELIVERY; BIOMEDICAL APPLICATIONS; LOADED LIPOSOMES; LIPID-MEMBRANES; NANOCAPSULES; STABILITY; MAGNETOLIPOSOMES; NANOPARTICLES; MULTILAYERS;

D O I：

10.1021/la9003142

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Superparamagnetic nanoparticles were encapsulated in liposomes prior to the stepwise adsorption of polyelectrolytes of opposite charges commonly known as the layer-by-layer (LbL) technique. Magnetic fields allow a fast separation of coated liposomes from unbound polyelectrolytes. The coated particles were characterized by dynamic light scattering (DLS), cryo-TEM, AFM, and zeta-potential techniques. The presence of magnetic nanoparticles and the polyelectrolyte shell opens the possibility of their magnetic manipulation and targeting by applying an external magnetic or electric Field.

引用

页码：6793 / 6799

页数：7

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