Mycotoxins as human carcinogens-the IARC Monographs classification

被引：639
作者：
Ostry, Vladimir [1 ]
Malir, Frantisek [2 ]
Toman, Jakub [2 ]
Grosse, Yann [3 ]
机构：
[1] Natl Inst Publ Hlth Prague, Ctr Hlth Nutr & Food, Palackeho 3a, Brno 61242, Czech Republic
[2] Univ Hradec Kralove, Fac Sci, Dept Biol, Rokitanskeho 62, Hradec Kralove 50003, Czech Republic
[3] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France
来源：
MYCOTOXIN RESEARCH | 2017年 / 33卷 / 01期
关键词：
Mycotoxins; Aflatoxins; Fumonisins; Ochratoxin A; IARC; Carcinogenicity; 2'-DEOXYGUANOSINE-CARBON 8-BOUND OCHRATOXIN; RENAL TUMOR-FORMATION; DNA-DAMAGE; ARISTOLOCHIC ACID; ADDUCT FORMATION; MALE RATS; IN-VIVO; KIDNEY; GENOTOXICITY; EXPOSURE;
D O I：
10.1007/s12550-016-0265-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Humans are constantly exposed to mycotoxins (e.g. aflatoxins, ochratoxins), mainly via food intake of plant and animal origin. The health risks stemming from mycotoxins may result from their toxicity, in particular their carcinogenicity. In order to prevent these risks, the International Agency for Research on Cancer (IARC) in Lyon (France)-through its IARC Monographs programme-has performed the carcinogenic hazard assessment of some mycotoxins in humans, on the basis of epidemiological data, studies of cancer in experimental animals and mechanistic studies. The present article summarizes the carcinogenic hazard assessments of those mycotoxins, especially aflatoxins (aflatoxin B-1, B-2, G(1), G(2) and M-1), fumonisins (fumonisin B-1 and B-2) and ochratoxin A (OTA). New information regarding the genotoxicity of OTA (formation of OTA-DNA adducts), the role of OTA in oxidative stress and the identification of epigenetic factors involved in OTA carcinogenesis-should they indeed provide strong evidence that OTA carcinogenicity is mediated by a mechanism that also operates in humans-could lead to the reclassification of OTA.
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收藏
页码：65 / 73
页数：9
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