Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age

被引：1

作者：

Teo, Wan-Yee ^{[1
]}

Ross, Jennifer ^{[2
]}

Bollo, Robert J. ^{[3
,4
]}

Seow, Wan-Tew ^{[5
]}

Tan, Ah-Moy ^{[6
]}

Kang, Seok-Gu ^{[7
]}

Kim, Dong-Seok ^{[7
]}

Li, Xiao-Nan ^{[1
,4
]}

Lau, Ching C. ^{[1
,4
]}

Mohila, Carrie A. ^{[2
]}

Adesina, Adekunle M. ^{[2
,4
]}

Su, Jack M. ^{[1
,4
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Div Hematol Oncol, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Texas Childrens Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[3] Baylor Coll Med, Texas Childrens Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

[4] Baylor Coll Med, Texas Childrens Canc Ctr, Dan L Duncan Canc Ctr, Houston, TX 77030 USA

[5] KK Womens & Childrens Hosp, Dept Neurosurg, Singapore, Singapore

[6] KK Womens & Childrens Hosp, Dept Pediat Subspecialties, Hematol Oncol Serv, Singapore, Singapore

[7] Yonsei Univ, Coll Med, Severance Childrens Hosp, Dept Pediat Neurosurg, Seoul 120749, South Korea

来源：

JOURNAL OF NEUROSURGERY-PEDIATRICS | 2014年 / 14卷 / 04期

关键词：

intracranial germ cell tumors; infants; oncology; excluding mature teratoma; CENTRAL-NERVOUS-SYSTEM; OF-THE-LITERATURE; YOLK-SAC TUMOR; PRIMARY CHEMOTHERAPY; BRAIN-TUMORS; EXPERIENCE; RADIATION; GERMINOMA; ALPHA(1)-FETOPROTEIN; CHILDHOOD;

D O I：

10.3171/2014.6.PEDS13651

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors describe a series of 15 intracranial germ cell tumors (IGCTs) excluding mature teratomas; 3 cases in children younger than 3 years of age who were treated at 3 different international institutions over the course of 20 years, and 12 from a PubMed search. These tumors, with possible in utero origins, often occur in atypical locations. The clinical behavior differed significantly from these tumors' counterparts in older children. In this young age group germinoma is highly aggressive, whereas nongerminomatous germ cell tumors may be cured without radiotherapy. Ongoing genomic studies reveal insights to attain an understanding of the biology of these tumors. New treatment strategies are needed to improve outcomes for IGCTs in this age group, particularly for germinomas.

引用

页码：348 / 355

页数：8

共 27 条

[1] Unusual anatomic location of a primary intracranial yolk sac tumor [J].

Al-Masri, Anwar A. ;

Khasawneh, Nidal H. ;

Aladily, Tariq N. .

ANNALS OF SAUDI MEDICINE, 2011, 31 (03) :298-300

[2] Pattern of relapse and outcome of non-metastatic germinoma patients treated with chemotherapy and limited field radiation: the SFOP experience [J].

Alapetite, Claire ;

Brisse, Herve ;

Patte, Catherine ;

Raquin, Marie Anne ;

Gaboriaud, Genevieve ;

Carrie, Christian ;

Habrand, Jean Louis ;

Thiesse, Philippe ;

Cuilliere, Jean Claude ;

Bernier, Valerie ;

Ben-Hassel, M. ;

Frappaz, Didier ;

Baranzelli, Marie Christine ;

Bouffet, Eric .

NEURO-ONCOLOGY, 2010, 12 (12) :1318-+

[3] NEOADJUVANT CHEMOTHERAPY FOR NEWLY DIAGNOSED GERM-CELL TUMORS OF THE CENTRAL-NERVOUS-SYSTEM [J].

ALLEN, JC ;

KIM, JH ;

PACKER, RJ .

JOURNAL OF NEUROSURGERY, 1987, 67 (01) :65-70

[4] GERMINOMA IN A 16-MONTH OLD BABY - A CASE-REPORT WITH BRIEF REVIEW OF THE LITERATURE [J].

AMMAR, A ;

ALMAJID, H ;

KUTTY, MK .

ACTA NEUROCHIRURGICA, 1991, 110 (3-4) :189-192

[5]

[Anonymous], 2007, WHO CLASSIFICATION T

[6] INFANT BRAIN TUMORS: INCIDENCE, SURVIVAL, AND THE ROLE OF RADIATION BASED ON SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) DATA [J].

Bishop, Andrew J. ;

McDonald, Mark W. ;

Chang, Andrew L. ;

Esiashvili, Natia .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (01) :341-347

[7] Alpha1-fetoprotein (AFP) reference values in infants up to 2 years of age [J].

Blohm, MEG ;

Vesterling-Horner, D ;

Calaminus, G ;

Gobel, U .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1998, 15 (02) :135-142

[8] AFP/β-HCG secreting CNS germ cell tumors:: Long-term outcome with respect to initial symptoms and primary tumor resection.: Results of the cooperative trial MAKEI 89 [J].

Calaminus, G ;

Bamberg, N ;

Harms, D ;

Jürgens, H ;

Kortmann, RD ;

Sörensen, N ;

Wiestler, OD ;

Göbel, U .

NEUROPEDIATRICS, 2005, 36 (02) :71-77

[9] Primary endodermal sinus tumor of the cerebellar hemisphere: a case report with review of the literature [J].

Cheon, Hyo-Cheol ;

Jung, Shin ;

Moon, Kyung-Sub ;

Lee, Min-Cheol ;

Kim, In-Young ;

Jung, Tae-Young ;

Kim, Soo-Han ;

Kang, Sam-Suk .

JOURNAL OF NEURO-ONCOLOGY, 2006, 77 (02) :173-176

[10] Primary Chemotherapy for Intracranial Germ Cell Tumors: Results of the Third International CNS Germ Cell Tumor Study [J].

da Silva, Nasjla Saba ;

Cappellano, Andrea M. ;

Diez, Blanca ;

Cavalheiro, Sergio ;

Gardner, Sharon ;

Wisoff, Jeffrey ;

Kellie, Stewart ;

Parker, Robert ;

Garvin, James ;

Finlay, Jonathan .

PEDIATRIC BLOOD & CANCER, 2010, 54 (03) :377-383

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