Prospects for magnetic nanoparticles in systemic administration: synthesis and quantitative detection

被引：19

作者：

Gutierrez, L. ^{[1
]}

Morales, M. P. ^{[1
]}

Lazaro, F. J. ^{[2
]}

机构：

[1] CSIC, Inst Ciencia Mat Madrid, Dept Biomat & Bioinspired Mat, Madrid 28049, Spain

[2] Univ Zaragoza, Dept Mat & Fluids Sci & Technol, Zaragoza 50018, Spain

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2014年 / 16卷 / 10期

基金：

欧盟第七框架计划;

关键词：

IRON-OXIDE NANOPARTICLES; BIOMEDICAL APPLICATIONS; DRUG-DELIVERY; SUPERPARAMAGNETIC NANOPARTICLES; QUANTIFICATION; FERRITIN; BIOTRANSFORMATION; BIODISTRIBUTION; BIODEGRADATION; NANOMATERIALS;

D O I：

10.1039/c3cp54763a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Methods for the quantitative determination of magnetic nanoparticles in biological matrices, in the frame of biomedical applications, are required to evaluate the particles biodistribution after systemic administration. AC magnetic susceptibility measurements are an alternative method to quantify magnetic nanoparticles in tissues, being able to provide also information on the particle transformations over time and allowing the distinction of the particles from other endogenous species such as the ferritin iron cores. The protocol for particle quantification using AC magnetic susceptibility measurements is described in detail in this article. A summary of synthesis routes towards magnetic nanoparticles is also provided.

引用

页码：4456 / 4464

页数：9

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