Poly(β,L-malic acid)/Doxorubicin ionic complex: A pH-dependent delivery system

被引：28
|
作者：
Lanz-Landazuri, Alberto [1 ]
Martinez de Ilarduya, Antxon [1 ]
Garcia-Alvarez, Montserrat [1 ]
Munoz-Guerra, Sebastian [1 ]
机构：
[1] Univ Politecn Cataluna, ETSEIB, Dept Engn Quim, E-08028 Barcelona, Spain
来源：
REACTIVE & FUNCTIONAL POLYMERS | 2014年 / 81卷
关键词：
Poly(malic acid); Ionic complexes; Doxorubicin complex; pH-dependent; Drug-delivery particle; DRUG-DELIVERY; POLY(BETA-L-MALIC ACID); POLY(BETA-MALIC ACID); POLYMERIC MICELLES; CONTROLLED-RELEASE; ANTICANCER DRUGS; BLOCK-COPOLYMERS; DOXORUBICIN; NANOPARTICLES; ENCAPSULATION;
D O I：
10.1016/j.reactfunctpolym.2014.04.005
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Poly(beta,L-malic acid) (PMLA) was made to interact with the cationic anticancer drug Doxorubicin (DOX) in aqueous solution to form ionic complexes with different compositions and an efficiency near to 100%. The PMLA/DOX complexes were characterized by spectroscopy, thermal analysis, and scanning electron microscopy. According to their composition, the PMLA/DOX complexes spontaneously self-assembled into spherical micro or nanoparticles with negative surface charge. Hydrolytic degradation of PMLA/DOX complexes took place by cleavage of the main chain ester bond and simultaneous release of the drug. In vitro drug release studies revealed that DOX delivery from the complexes was favored by acidic pH and high ionic strength. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：45 / 53
页数：9
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