Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity

被引：83

作者：

He, Zhongmei ^{[1
]}

Chen, Hongyan ^{[1
]}

Li, Guofeng ^{[2
]}

Zhu, Hongyan ^{[1
]}

Gao, Yugang ^{[1
]}

Zhang, Lianxue ^{[1
]}

Sun, Jiaming ^{[3
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[2] Changchun Univ Tradit Chinese Med, Changchun Univ Tradit Med, Affiliated Hosp 1, Changchun 130021, Peoples R China

[3] Changchun Univ Tradit Chinese Med, Dev Ctr Tradit Chinese Med & Bioengn, Changchun 130117, Peoples R China

来源：

PHYTOMEDICINE | 2014年 / 21卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Diosgenin; Breast cancer; Migration; Actin polymerization; Vav2; Cdc42; RHO-GTPASES; ADHESION; CDC42;

D O I：

10.1016/j.phymed.2014.02.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Diosgenin, a naturally occurring steroidal saponin, possess tumor therapeutic potential. However, the effect of diosgenin on cancer metastasis remains poorly understood. In this study, we performed in vitro experiments to investigate the inhibitory activity of diosgenin on human breast cancer MDA-MB-231 cell migration, and reveal the possible mechanism. Diosgenin caused a marked inhibition of cell migration in MDA-MB-231 cell by transwell assay. In addition, diosgenin significantly impacted MDA-MB-231 cell migratory behavior under real-time observation. We also found diosgenin significantly inhibited actin polymerization, Vav2 phosphorylation and Cdc42 activation, which might be, at least in part, attributed to the anti-metastatic potential of diosgenin. These findings reveal a new therapeutic potential of diosgenin for human breast cancer metastasis therapy. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：871 / 876

页数：6

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