Signaling by distinct classes of phosphoinositide 3-kinases

被引：767
作者：
Vanhaesebroeck, B
Waterfield, MD
机构：
[1] Ludwig Inst Canc Res, London W1P 8BT, England
[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
来源：
EXPERIMENTAL CELL RESEARCH | 1999年 / 253卷 / 01期
关键词：
D O I：
10.1006/excr.1999.4701
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affecting their localization, conformation, and activities. Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation. (C) 1999 Academic Press.
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页码：239 / 254
页数：16
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