Osteogenic Effect of Hybrid Scaffolds Composed of Duck Feet Collagen and PLGA

被引：5

作者：

Kuk, Hyeon ^{[1
,2
]}

Kin, Hye Min ^{[1
,2
]}

Kim, Soo Min ^{[1
,2
]}

Kim, Eun Young ^{[1
,2
]}

Song, Jeong Eun ^{[1
,2
]}

Kwon, Soon Yong ^{[3
]}

Suh, Dong Sam ^{[4
]}

Park, Chan Hum ^{[5
]}

Khang, Gilson ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Polymer Fus Res Ctr, Dept BIN Fus Tech, Jeonju 561756, Chonbuk, South Korea

[2] Chonbuk Natl Univ, Dept PolymerNano Sci Tech, Jeonju 561756, Chonbuk, South Korea

[3] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Ortheped Surg, Seoul 150896, South Korea

[4] Sewon Cellontech, Wooyoung Techno Ctr, Seoul 133831, South Korea

[5] Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Dept Otorhinolaryngol Head & Neck Surg, Chunchon 200702, Gangwon, South Korea

来源：

POLYMER-KOREA | 2015年 / 39卷 / 06期

关键词：

PLGA scaffold; collagen; ducks collagen; bone marrow mesenchymal stem cells (BMSC); bone regeneration; bone reconstruction; BONE; HYDROXYAPATITE; PRODUCTS; SAFETY; SKIN; CELL;

D O I：

10.7317/pk.2015.39.6.846

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Duck feet collagen (DC) has recently been used as a stable and safe source for tissue engineering. In this study, we have prepared a series of collagen scaffolds by mixing poly(lactic-co-glycolide)(PLGA) solutions with different percentages of collagen extracted from duck feet. Bone marow mesenchymal stem cells (BMSC) were cultured on the prepared DC/PLGA scaffolds, and their osteogenic effect and bone formation were compared systemically. At 7 days after seeding, osteogenisis was significantly increased on PLGA scaffolds containing upto 80% of DC. However, the alkaline phosphatase activity of DC/PLGA scaffolds decreased gradually after the first week and reached to the basal line after 14 days. This result indicates that DC/PLGA hybrid scaffolds are helpful for initial bone formation and differentiation, and have a positive effect on them.

引用

页码：846 / 851

页数：6

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