Dynamic structural flexibility of α-synuclein

被引：62

作者：

Mor, Danielle E. ^{[1
]}

Ugras, Scott E. ^{[2
]}

Daniels, Malcolm J. ^{[3
]}

Ischiropoulos, Harry ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Univ Penn, Raymond & Ruth Perelman Sch Med, Biomed Grad Studies Neurosci, Philadelphia, PA 19104 USA

[2] Univ Penn, Raymond & Ruth Perelman Sch Med, Biomed Grad Studies Biochem & Mol Biophys, Philadelphia, PA 19104 USA

[3] Univ Penn, Raymond & Ruth Perelman Sch Med, Biomed Grad Studies Pharmacol, Philadelphia, PA 19104 USA

[4] Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA

[5] Univ Penn, Raymond & Ruth Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[6] Univ Penn, Raymond & Ruth Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

来源：

NEUROBIOLOGY OF DISEASE | 2016年 / 88卷

基金：

美国国家卫生研究院;

关键词：

FAMILIAL PARKINSONS-DISEASE; N-TERMINAL ACETYLATION; FIBRIL FORMATION; IN-VITRO; MICE LACKING; HUMAN BRAIN; WILD-TYPE; MEMBRANE INTERACTIONS; HIPPOCAMPAL-NEURONS; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.nbd.2015.12.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha-Synuclein is a conserved, abundantly expressed protein that is partially localized in pre-synaptic terminals in the central nervous system. The precise biological function(s) and structure of alpha-synuclein are under investigation. Recently, the native conformation and the presence of naturally occurring multimeric assemblies have come under debate. These are important deliberations because alpha-synuclein assembles into highly organized amyloid-like fibrils and non-amyloid amorphous aggregates that constitute the neuronal inclusions in Parkinson's disease and related disorders. Therefore understanding the nature of the native and pathological conformations is pivotal from the standpoint of therapeutic interventions that could maintain alpha-synuclein in its physiological state. In this review, we will discuss the existing evidence that define the physiological states of alpha-synuclein and highlight how the inherent structural flexibility of this protein may be important in health and disease. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.

引用

页码：66 / 74

页数：9

共 116 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].