Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity

被引：51

作者：

Zhou, Lili ^{[1
]}

Zheng, Danhua ^{[1
]}

Wang, Miao ^{[1
]}

Cong, Yu-Sheng ^{[1
]}

机构：

[1] Beijing Normal Univ, Key Lab Cell Proliferat & Regulat Biol, Minist Educ, Inst Cell Biol,Coll Life Sci, Beijing 100875, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 386卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Telomerase; hTERT; VEGF; HUMAN FIBROBLASTS; CANCER; GENE; INHIBITION; PROTEIN;

D O I：

10.1016/j.bbrc.2009.06.116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase is almost universally required for cellular immortality and is permissive for tumorigenesis. Accumulating evidence suggests that telomerase may have roles in cellular processes independent of its role in telomere maintenance. However, the biochemical properties and the mechanisms of telomerase non-telomeric functions are unknown. In this report, we show that the telomerase catalytic component hTERT is capable of activating transcription of VEGF. We further demonstrated that the activation of VEGF expression by hTERT was independent of telomerase activity and telomere maintenance. These results suggest that hTERT has non-telomeric activity in the regulation of gene expression and provide additional insights into the role of telomerase in aging and cancer. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：739 / 743

页数：5

共 34 条

[1]

[Anonymous], 2008, OCEANS 2008

[2] Genes and pathways downstream of telomerase in melanoma metastasis [J].

Bagheri, Sepideh ;

Nosrati, Mehdi ;

Li, Shang ;

Fong, Sylvia ;

Torabian, Sima ;

Rangel, Javier ;

Moore, Dan H. ;

Federman, Scot ;

LaPosa, Rebecca R. ;

Baehner, Frederick L. ;

Sagebiel, Richard W. ;

Cleaver, James E. ;

Haqq, Christopher ;

Debs, Robert J. ;

Blackburn, Elizabeth H. ;

Kashani-Sabet, Mohammed .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11306-11311

[3] VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent [J].

Bennudez, Yira ;

Yang, Hua ;

Saunders, Beatriz O. ;

Cheng, Jin Q. ;

Nicosia, Santo V. ;

Kruk, Patricia A. .

GYNECOLOGIC ONCOLOGY, 2007, 106 (03) :526-537

[4] Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging [J].

Blasco, MA .

EMBO JOURNAL, 2005, 24 (06) :1095-1103

[5] VEGF in biological control [J].

Breen, Ellen C. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 102 (06) :1358-1367

[6] Aging and survival of cutaneous microvasculature [J].

Chang, E ;

Yang, JW ;

Nagavarapu, U ;

Herron, GS .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 118 (05) :752-758

[7] Telomerase extracurricular activities [J].

Chang, S ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12520-12522

[8] TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program [J].

Choi, Jinkuk ;

Southworth, Lucinda K. ;

Sarin, Kavita Y. ;

Venteicher, Andrew S. ;

Ma, Wenxiu ;

Chang, Woody ;

Cheung, Peggie ;

Jun, Sohee ;

Artandi, Maja K. ;

Shah, Naman ;

Kim, Stuart K. ;

Artandi, Steven E. .

PLOS GENETICS, 2008, 4 (01) :0124-0138

[9] The biogenesis and regulation of telomerase holoenzymes [J].

Collins, Kathleen .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (07) :484-494

[10] Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence [J].

Coppe, Jean-Philippe ;

Kauser, Katalin ;

Campisi, Judith ;

Beausejour, Christian M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (40) :29568-29574

← 1 2 3 4 →