Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole -: a CYP1A2 inducer

被引：8

作者：

Suzuki, S

Takahashi, S

Asamoto, M

Inaguma, S

Ogiso, T

Hirose, M

Shirai, T

机构：

[1] Nagoya City Univ, Sch Med, Dept Pathol 1, Mizuho Ku, Nagoya, Aichi 4678601, Japan

[2] Natl Inst Hlth Sci, Div Pathol, Tokyo, Japan

来源：

CANCER LETTERS | 2002年 / 185卷 / 01期

关键词：

2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; fenbendazole; CYP1A2; hepatocarcinogenesis; rat;

D O I：

10.1016/S0304-3835(02)00243-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fenbendazole (FBZ) is an anthelmintic drug known to be a potent CYP1A2 inducer. Combined effects of FBZ on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats were investigated using a medium-term liver bioassay system. No modifying influence was found in terms of glutathione S-transferase placental-form positive foci development although CYP1A2 protein expression in the livers of rats that were given MelQx and FBZ was 2.3-fold higher than with MelQx alone. NAT2 mRNA expression did not differ among the groups as revealed by quantitative reverse transcriptase-polymerase chain reaction analysis. These results suggest that elevated CYP1A2 expression is not sufficient to enhance MelQx-induced hepatocarcinogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：39 / 45

页数：7

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