β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A Review

被引：73

作者：

Marcelino, Gabriela ^{[1
]}

Machate, David Johane ^{[2
]}

Freitas, Karine de Cassia ^{[1
]}

Hiane, Priscila Aiko ^{[1
]}

Maldonade, Iriani Rodrigues ^{[3
]}

Pott, Arnildo ^{[4
]}

Asato, Marcel Arakaki ^{[5
]}

Candido, Camila Jordao ^{[1
]}

Avellaneda Guimaraes, Rita de Cassia ^{[1
]}

机构：

[1] Univ Fed Mato Grosso do Sul, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil

[2] Univ Fed Mato Grosso do Sul, Grad Program Sci Mat, Grp Spect & Bioinformat Appl Biodivers & Hlth GEB, BR-79070900 Campo Grande, MS, Brazil

[3] Brazilian Agr Res Corp Embrapa Vegetables, Lab Food Sci & Technol, BR-70275970 Brasilia, DF, Brazil

[4] Univ Fed Mato Grosso do Sul, Inst Biosci, Lab Bot, BR-79070900 Campo Grande, MS, Brazil

[5] Univ Fed Mato Grosso do Sul, Fac Med, BR-79070900 Campo Grande, MS, Brazil

来源：

MOLECULES | 2020年 / 25卷 / 24期

关键词：

oxidative stress; dyslipidemia; antioxidants; insulin resistance; METABOLIC SYNDROME; INSULIN-RESISTANCE; SERUM CAROTENOIDS; LOWER PREVALENCE; ANTIOXIDANTS; DEGRADATION; CHOLESTEROL; ABSORPTION; ADIPOKINES; ADIPOSITY;

D O I：

10.3390/molecules25245803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carotenoids are vital antioxidants for plants and animals. They protect cells from oxidative events and act against the inflammatory process and carcinogenesis. Among the most abundant carotenoids in human and foods is beta-carotene. This carotenoid has the highest level of provitamin A activity, as it splits into two molecules of retinol through the actions of the cytosolic enzymes: beta-carotene-15,15 '-monooxygenase (beta-carotene-15,15 '-oxygenase 1) and beta-carotene-9 ',10 '-dioxygenase (beta-carotene-9 ',10 '-oxygenase 2). The literature supports the idea that beta-carotene acts against type 2 diabetes mellitus, cardiovascular diseases, obesity, and metabolic syndrome. Due to the many processes involved in beta-carotene biosynthesis and metabolic function, little is known about such components, since many mechanisms have not yet been fully elucidated. Therefore, our study concisely described the relationships between the consumption of carotenoids, with emphasis on beta-carotene, and obesity and type 2 diabetes mellitus and its associated parameters in order to understand the preventive role of carotenoids better and encourage their consumption.

引用

页数：14

共 68 条

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