Guided Bone Regeneration Effect by Chitosan/Hydroxyapatite Membrane on Repair of Rat Calvarial Defect

The synthetic scaffolds for bone augmentation fill the cavity, and act as a template for initial cell ingrowth and subsequent tissue formation. The desirable material as a scaffold need resorbable biomimetics, biocompatibility, mechanical stability, and cell viability. Hydroxyapatite is a synthetic calcium phosphate that resembles bone mineral. Its surface is highly reactive and favorable for attachment. Hydroxyapatite has properties such as biocompatibility, non-toxicity, osseoconductivity. And chitosan is one of the biodegradable polymers in nature. Chitosan has non-toxicity, flexibility, anti-bacterial effect, resistance to heat, and biocompatibility. Mixture of hydroxyapatite and chitosan promotes osteoblastic adhesion, migration, differentiation, and proliferation. This mixture were prepared for the function of guided bone regeneration(GBR). This study makes the chitosan/fibroin-hydroxyapatite composite membrane be a prospective biodegradable GBR membrane for future applications.