Glucocorticoid receptor expression in breast cancer associates with older patient age

被引：30

作者：

Belova, Larissa ^{[1
]}

Delgado, Bertha ^{[3
]}

Kocherginsky, Masha ^{[4
]}

Melhem, Amal ^{[1
]}

Olopade, Olufunmilayo I. ^{[1
]}

Conzen, Suzanne D. ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[2] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[4] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2009年 / 116卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Estrogen receptor; Progesterone receptor; HER2; Glucocorticoid receptor; Triple-negative disease; Health disparities; DIFFERENTIAL EXPRESSION; APOPTOSIS; SURVIVAL; CELLS; WOMEN; INHIBITION; ESTRADIOL; ESTROGEN; SUBTYPES; GENES;

D O I：

10.1007/s10549-008-0136-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer can be classified according to estrogen (ER), progesterone (PR), and HER2 receptor expression. Recent evidence suggests that activation of the glucocorticoid receptor (GR) contributes to breast cell survival, although the incidence of GR expression in primary human breast tumors is not well established. We therefore evaluated ER, PR, HER2, and GR by immunohistochemistry from 231 patients and found that while African American (AA) patient tumors were much more likely to be ER negative compared to tumors from non-AA patients, GR expression was significantly higher in tumors from patients a parts per thousand yen50 regardless of ancestry. Prospective examination of GR expression in tumors should be considered to determine whether GR contributes to long-term clinical outcome.

引用

页码：441 / 447

页数：7

共 30 条

[1] Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inflammatory action [J].