Analysis of Th1, Th17 and regulatory T cells in tuberculosis case contacts

被引：21
作者：
Garcia Jacobo, R. E. [1 ]
Serrano, C. J. [1 ]
Enciso Moreno, J. A. [1 ]
Gaspar Ramirez, O. [3 ]
Trujillo Ochoa, J. L. [1 ]
Uresti Rivera, E. E. [2 ]
Portales Perez, D. P. [2 ]
Gonzalez-Amaro, R. [4 ]
Garcia Hernandez, M. H. [1 ]
机构：
[1] Inst Mexicano Seguro Social, Unidad Invest Med Zacatecas, Interior Alameda 45, Zacatecas 98000, Zac, Mexico
[2] UASLP, Fac Ciencias Quim, Dept Inmunol & Biol Celular & Mol, San Luis Potosi, Slp, Mexico
[3] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, AC Unidad Noreste, Monterrey, Nuevo Leon, Mexico
[4] UASLP, Fac Med, Dept Inmunol, San Luis Potosi, Slp, Mexico
来源：
CELLULAR IMMUNOLOGY | 2014年 / 289卷 / 1-2期
关键词：
Tuberculosis case contacts; Immune response; T lymphocytes; Mycobacteria; TB spectrum; HEALTH-CARE WORKERS; INTERFERON-GAMMA; LATENT TUBERCULOSIS; CYTOKINE PRODUCTION; ELISPOT TEST; SKIN-TEST; INFECTION; RESPONSES; MYCOBACTERIA; VACCINATION;
D O I：
10.1016/j.cellimm.2014.03.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have hypothesized that individuals infected with Mycobacterium tuberculosis that exhibit different patterns of immune reactivity in serial interferon (IFN)-gamma release assays (IGRA's) correspond to different status within the immune spectrum of latent tuberculosis (TB). Accordingly, we analyzed the possible association between the consistent results (negative or positive) in an IGRA test and relevant immune parameters, mainly the levels of Thl and Th17 lymphocytes and T regulatory (Treg) cells in the peripheral blood of TB case contacts. We found that individuals with a persistently positive IGRA showed increased levels of Thl and Th17 lymphocytes upon in vitro stimulation with MTB antigens. In addition, a significant increase in the proportion of CD4+CTLA-4+ and CD4+Foxp3+ cells was detected in assays with blood samples from these individuals. Our data support that different immune phenotypes can be identified into the spectrum of latent TB, by combining different parameters of immune reactivity against MTB. (c) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：167 / 173
页数：7
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