Cancer-associated fibroblasts-stimulated interleukin-11 promotes metastasis of gastric cancer cells mediated by upregulation of MUC1

被引：47

作者：

Wang, Xiaoxun ^{[1
,2
]}

Che, Xiaofang ^{[1
,2
]}

Liu, Chang ^{[1
,2
]}

Fan, Yibo ^{[1
,2
]}

Bai, Ming ^{[1
,2
]}

Hou, Kezuo ^{[1
,2
]}

Shi, Xiaonan ^{[1
,2
]}

Zhang, Xiaojie ^{[1
,2
]}

Liu, Bofang ^{[1
,2
]}

Zheng, Chunlei ^{[1
,2
]}

Liu, Yunpeng ^{[1
,2
]}

Qu, Xiujuan ^{[1
,2
]}

机构：

[1] China Med Univ, Dept Med Oncol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Key Lab Anticanc Drugs & Biotherapy Liaoning Prov, Hosp 1, Shenyang 110001, Liaoning, Peoples R China

来源：

EXPERIMENTAL CELL RESEARCH | 2018年 / 368卷 / 02期

基金：

中国国家自然科学基金;

关键词：

IL-11; Invasion; Migration; MUC1; CAFs; GROWTH-FACTOR; STROMAL FIBROBLASTS; TUMOR PROGRESSION; RECEPTOR-ALPHA; IL-11; RECEPTOR; EXPRESSION; CARCINOMA; STAT3; GENE; ADENOCARCINOMA;

D O I：

10.1016/j.yexcr.2018.04.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer-associated fibroblasts (CAFs) are major components of the tumor stroma and regulators of tumor progression. However, the molecular mechanism by which CAFs promote gastric cancer progressioh should be further explored. In our study, we found that interleukin-11 (IL-11) secretion was significantly increased when CAFs were co-cultured with gastric cancer cells. Co-culture system-derived IL-11 promoted the migration and invasion of gastric cancer cells, whereas the increase of migration and invasion was attenuated by a neutralizing antibody of IL-11 or inhibition of JAK/STAT3 and MAPIVERK pathways with specific inhibitors. Taken together, these results revealed that CAFs play a significant role in the gastric cancer progression in the tumor micro environment through IL-11-STAT3/ERK signaling by upregulating MUC1. Also, IL-11 targeted therapy can achieve an effective treatment against gastric cancer indirectly by exerting their action on stromal fibroblasts.

引用

页码：184 / 193

页数：10

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