RNAi in moderation

被引：25

作者：

Barik, Sailen ^{[1
]}

机构：

[1] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 07期

关键词：

D O I：

10.1038/nbt0706-796

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new animal study shows that too much RNAi is lethal.

引用

页码：796 / 797

页数：3

共 12 条

[1] Inhibition of respiratory viruses by nasally administered siRNA [J].

Bitko, V ;

Musiyenko, A ;

Shulyayeva, O ;

Barik, S .

NATURE MEDICINE, 2005, 11 (01) :50-55

[2] Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses [J].

Bitko V. ;

Barik S. .

BMC Microbiology, 1 (1) :1-11

[3] microPrimer: The biogenesis and function of microRNA [J].

Du, TT ;

Zamore, PD .

DEVELOPMENT, 2005, 132 (21) :4645-4652

[4] Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways [J].

Grimm, Dirk ;

Streetz, Konrad L. ;

Jopling, Catherine L. ;

Storm, Theresa A. ;

Pandey, Kusum ;

Davis, Corrine R. ;

Marion, Patricia ;

Salazar, Felix ;

Kay, Mark A. .

NATURE, 2006, 441 (7092) :537-541

[5] Sequence-specific inhibition of small RNA function [J].

Hutvágner, G ;

Simard, MJ ;

Mello, CC ;

Zamore, PD .

PLOS BIOLOGY, 2004, 2 (04) :465-475

[6] Expression profiling reveals off-target gene regulation by RNAi [J].

Jackson, AL ;

Bartz, SR ;

Schelter, J ;

Kobayashi, SV ;

Burchard, J ;

Mao, M ;

Li, B ;

Cavet, G ;

Linsley, PS .

NATURE BIOTECHNOLOGY, 2003, 21 (06) :635-637

[7] Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner [J].

Lugli, G ;

Larson, J ;

Martone, ME ;

Jones, Y ;

Smalheiser, NR .

JOURNAL OF NEUROCHEMISTRY, 2005, 94 (04) :896-905

[8] Activation of the mammalian immune system by siRNAs [J].

Marques, JT ;

Williams, BRG .

NATURE BIOTECHNOLOGY, 2005, 23 (11) :1399-1405

[9] Revealing the world of RNA interference [J].

Mello, CC ;

Conte, D .

NATURE, 2004, 431 (7006) :338-342

[10] Second-generation shRNA libraries covering the mouse and human genomes [J].

Silva, JM ;

Li, MZ ;

Chang, K ;

Ge, W ;

Golding, MC ;

Rickles, RJ ;

Siolas, D ;

Hu, G ;

Paddison, PJ ;

Schlabach, MR ;

Sheth, N ;

Bradshaw, J ;

Burchard, J ;

Kulkarni, A ;

Cavet, G ;

Sachidanandam, R ;

McCombie, WR ;

Cleary, MA ;

Elledge, SJ ;

Hannon, GJ .

NATURE GENETICS, 2005, 37 (11) :1281-1288

← 1 2 →