The Endothelin Pathway: A Protective or Detrimental Target of Bardoxolone Methyl on Cardiac Function in Patients with Advanced Chronic Kidney Disease?

被引：8
作者：
Camer, Danielle
Huang, Xu-Feng
机构：
[1] Univ Wollongong, Sch Med, Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia
来源：
AMERICAN JOURNAL OF NEPHROLOGY | 2014年 / 40卷 / 03期
关键词：
Endothelin; Kidney; Renal; Heart; Bardoxolone methyl; EVENTS; CKD;
D O I：
10.1159/000368563
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Bardoxolone methyl has been reported to cause detrimental cardiovascular events in the terminated BEACON Phase Ill human clinical trial via modulation of the renal endothelin pathway. However, the effects of bardoxolone methyl administration on the endothelin pathway in the heart are unknown. Our purpose in this perspective is to highlight the distinctive opposing roles of the renal and heart endothelin pathway in cardiac function. Furthermore, we address the need for further investigation in order to determine if bardoxolone methyl has a protective role in cardiac function through the suppression of the endothelin pathway in the heart. (C) 2014 S. Karger AG, Basel
引用
收藏
页码：288 / 290
页数：3
相关论文
共 9 条
[1]   The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications [J].
Camer, Danielle ;
Yu, Yinghua ;
Szabo, Alexander ;
Huang, Xu-Feng .
MOLECULAR NUTRITION & FOOD RESEARCH, 2014, 58 (08) :1750-1759
[2]   Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl [J].
Chin, Melanie P. ;
Reisman, Scott A. ;
Bakris, George L. ;
O'Grady, Megan ;
Linde, Peter G. ;
McCullough, Peter A. ;
Packham, David ;
Vaziri, Nosratola D. ;
Ward, Keith W. ;
Warnock, David G. ;
Meyer, Colin J. .
AMERICAN JOURNAL OF NEPHROLOGY, 2014, 39 (06) :499-508
[3]   Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease [J].
de Zeeuw, Dick ;
Akizawa, Tadao ;
Audhya, Paul ;
Bakris, George L. ;
Chin, Melanie ;
Christ-Schmidt, Heidi ;
Goldsberry, Angie ;
Houser, Mark ;
Krauth, Melissa ;
Heerspink, Hiddo J. Lambers ;
McMurray, John J. ;
Meyer, Colin J. ;
Parving, Hans-Henrik ;
Remuzzi, Giuseppe ;
Toto, Robert D. ;
Vaziri, Nosratola D. ;
Wanner, Christoph ;
Wittes, Janet ;
Wrolstad, Danielle ;
Chertow, Glenn M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (26) :2492-2503
[4]   Rationale and Trial Design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON) [J].
de Zeeuw, Dick ;
Akizawa, Tadao ;
Agarwal, Rajiv ;
Audhya, Paul ;
Bakrise, George L. ;
Chin, Melanie ;
Krauth, Melissa ;
Heerspink, Hiddo J. Lambers ;
Meyer, Colin J. ;
McMurray, John J. ;
Parving, Hans-Henrik ;
Pergola, Pablo E. ;
Remuzzi, Giuseppe ;
Toto, Robert D. ;
Vaziri, Nosratola D. ;
Wanner, Christoph ;
Warnock, David G. ;
Wittes, Janet ;
Chertow, Glenn M. .
AMERICAN JOURNAL OF NEPHROLOGY, 2013, 37 (03) :212-222
[5]   The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure [J].
Kohan, DE .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2006, 15 (01) :34-40
[6]  
Nasser SA, 2014, EUR J PHARMACOL, V737, P210, DOI [10.1016/J.EJPHAR.2014.05.046, 10.1016/j.ejphar.2014.05.046]
[7]   Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes [J].
Pergola, Pablo E. ;
Raskin, Philip ;
Toto, Robert D. ;
Meyer, Colin J. ;
Huff, J. Warren ;
Grossman, Eric B. ;
Krauth, Melissa ;
Ruiz, Stacey ;
Audhya, Paul ;
Christ-Schmidt, Heidi ;
Wittes, Janet ;
Warnock, David G. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (04) :327-336
[8]   Effect of Bardoxolone Methyl on Kidney Function in Patients with T2D and Stage 3b-4 CKD [J].
Pergola, Pablo E. ;
Krauth, Melissa ;
Huff, J. Warren ;
Ferguson, Deborah A. ;
Ruiz, Stacey ;
Meyer, Colin J. ;
Warnock, David G. .
AMERICAN JOURNAL OF NEPHROLOGY, 2011, 33 (05) :469-476
[9]   The paradox of bardoxolone methyl: a call for every witness on the stand? [J].
Van Laecke, S. ;
Van Biesen, W. ;
Vanholder, R. .
DIABETES OBESITY & METABOLISM, 2015, 17 (01) :9-14
1