Photodegradation kinetics of lisdexamfetamine dimesylate and structure elucidation of its degradation products by LC-ESI-QTOF

被引：1

作者：

Carlos, Graciela ^{[1
]}

Segalin, Jeferson ^{[2
]}

Jank, Louise ^{[2
]}

Comiran, Eloisa ^{[1
]}

de Oliveira, Marcella Herbstrith ^{[1
]}

Froehlich, Pedro Eduardo ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Fac Pharm, Grad Studies Program Pharmaceut Sci, Porto Alegre, RS, Brazil

[2] Minist Agr Livestock & Food Supply, Natl Agr Lab LANAGRO RS, Porto Alegre, RS, Brazil

来源：

ANALYTICAL METHODS | 2018年 / 10卷 / 19期

关键词：

TANDEM MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; ILLICIT DRUGS; WASTE-WATER; TAP WATERS; ABUSE; PHARMACEUTICALS; SURFACE; MS/MS; UV;

D O I：

10.1039/c8ay00413g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Herein, we investigate the photodegradation of lisdexamfetamine (LDX) in an aqueous solution. The experiment is carried out by exposing the drug in solution to UV radiation for different periods of time during 48 h. The fragmentation pattern of LDX is established, and its two degradation products are identified (DP-01 and DP-02) and structurally characterized via liquid chromatography coupled with hybrid quadrupole time-of-flight electrospray ionization (LC-ESI-QTOF) mass spectrometry. Furthermore, the photodegradation kinetics of LDX is determined via LC-ESI-QTOF (r = 0.9905; k = 0.0204 h(-1); and t(1/2) = 33.91 h) and RP-LC-CAD (r = 0.9960; k = 0.0234 h(-1); and t(1/2) = 29.67 h). LDX is found to be unstable in the presence of light under the evaluated conditions.

引用

页码：2287 / 2292

页数：6

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