Gender Differences in Depression: Evidence From Genetics

被引：71

作者：

Zhao, Lihong ^{[1
]}

Han, Guanghong ^{[2
]}

Zhao, Yinghao ^{[1
]}

Jin, Yang ^{[1
]}

Ge, Tongtong ^{[1
]}

Yang, Wei ^{[1
]}

Cui, Ranji ^{[1
]}

Xu, Songbai ^{[3
]}

Li, Bingjin ^{[1
]}

机构：

[1] Second Hosp Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Changchun, Peoples R China

[2] Jilin Univ, Hosp Stomatol, Dept Oral Geriatr, Changchun, Peoples R China

[3] First Hosp Jilin Univ, Dept Neurosurg, Changchun, Peoples R China

来源：

FRONTIERS IN GENETICS | 2020年 / 11卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

depression; gender difference; genetics; gene-environment interactions; heritability; LINKED POLYMORPHIC REGION; CHINESE HAN ADOLESCENTS; ENVIRONMENT INTERACTION; MAJOR DEPRESSION; LIFE EVENTS; SYMPTOMS; SEX; ASSOCIATION; 5-HTTLPR; STRESS;

D O I：

10.3389/fgene.2020.562316

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Compared with men, female accounts for a larger proportion of patients with depression. Behavioral genetics researches find gender differences in genetic underpinnings of depression. We found that gender differences exist in heritability and the gene associated with depression after reviewing relevant research. Both genes and gene-environment interactions contribute to the risk of depression in a gender-specific manner. We detailed the relationships between serotonin transporter gene-linked promoter region (5-HTTLPR) and depression. However, the results of these studies are very different. We explored the reasons for the contradictory conclusions and provided some suggestions for future research on the gender differences in genetic underpinnings of depression.

引用

页数：15

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