Characteristics of follicular fluid in ovaries with endometriomas

被引：21

作者：

Giacomini, Elisa ^{[1
]}

Sanchez, Ana M. ^{[1
]}

Sarais, Veronica ^{[1
]}

Al Beitawi, Soha ^{[1
]}

Candiani, Massimo ^{[2
,3
]}

Vigano, Paola ^{[1
]}

机构：

[1] IRCCS San Raffaele Sci Inst, Div Genet & Cell Biol, Reprod Sci Lab, Milan, Italy

[2] Univ Vita Salute San Raffaele, Milan, Italy

[3] IRCCS San Raffaele Hosp, Milan, Italy

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2017年 / 209卷

关键词：

Endometrioma; Follicular fluid; Iron; Reactive oxygen species; ANTI-MULLERIAN HORMONE; IN-VITRO FERTILIZATION; PRIMATE CORPUS-LUTEUM; OXIDATIVE STRESS; LAPAROSCOPIC CYSTECTOMY; SPONTANEOUS OVULATION; NEGATIVELY AFFECT; EMBRYO QUALITY; WOMEN; IRON;

D O I：

10.1016/j.ejogrb.2016.01.032

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The study of follicular fluid (FF) content nearby endometriomas may assist in elucidating pathophysiology, possible biomarkers related to this disease and the effect of endometriomas on ovarian physiology. As the question "how endometrioma may intrude the physiology of ovarian tissue?" is still open, we aimed to summarize the molecular evidence supporting the idea that endometriomas can negatively influence the content of the surrounding ovarian follicles. An alteration of the iron metabolism and an increased ROS (reactive oxygen species) generation characterize the intrafollicular environment adjacent to endometriomas. Other potentially negative effects include decreased testosterone and anti-Mullerian hormone FF levels although these have been only partially clarified. Alterations in lipid and proteomic patterns have been also observed in FF samples nearby endometriomas. The possibility that endometriomas per se may influence IVF clinical results as a consequence of the detrimental impact on the local intrafollicular environment is also discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：34 / 38

页数：5

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