Cardiovascular implications of idiopathic pulmonary fibrosis: A way forward together?

被引：11
作者：
Mosher, Christopher L. [1 ,2 ,4 ]
Mentz, Robert J. [1 ,3 ,5 ,6 ,7 ]
机构：
[1] Duke Clin Res Inst, POB 17969, Durham, NC 27715 USA
[2] Duke Univ, Med Ctr, Div Pulm & Crit Care Med, Durham, NC USA
[3] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Durham, NC 27710 USA
[5] Duke Univ, Med Ctr, Div Cardiol, Med, Durham, NC 27710 USA
[6] Duke Univ, Med Ctr, Populat Hlth Sci, Durham, NC USA
[7] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA
来源：
AMERICAN HEART JOURNAL | 2020年 / 226卷
基金：
美国国家卫生研究院;
关键词：
MATRIX METALLOPROTEINASES; MYOCARDIAL-INFARCTION; TISSUE INHIBITOR; HEART-FAILURE; LUNG; PIRFENIDONE; NINTEDANIB; DIAGNOSIS; DISEASE; HYPERTENSION;
D O I：
10.1016/j.ahj.2020.04.027
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular disease has an increased prevalence among patients with idiopathic pulmonary fibrosis (IPF). Cardiovascular disease and IPF share similar symptoms with overlapping demographics and risk factors for disease development. Common cellular mediators leading to disease development and progression have been identified in both the cardiovascular and pulmonary organ systems. In this context, discovery of new therapeutic targets and medical therapies could be mutually beneficial across cardiopulmonary diseases. Here we present (1) a clinical review of IPF for the cardiovascular clinician and (2) common cellular mechanisms responsible for fibrosis in the heart and lungs and (3) highlight future research considerations and the potential role of novel therapeutic agents which may be mutually beneficial in cardiac and pulmonary fibrosis.
引用
收藏
页码：69 / 74
页数：6
相关论文
共 70 条
[1]   JunD and HIF-1α mediate transcriptional activation of angiotensinogen by TGF-β1 in human lung fibroblasts [J].
Abdul-Hafez, Amal ;
Shu, Ruijie ;
Uhal, Bruce D. .
FASEB JOURNAL, 2009, 23 (06) :1655-1662
[2]   Targeting cardiac fibrosis with engineered T cells [J].
Aghajanian, Haig ;
Kimura, Toru ;
Rurik, Joel G. ;
Hancock, Aidan S. ;
Leibowitz, Michael S. ;
Li, Li ;
Scholler, John ;
Monslow, James ;
Lo, Albert ;
Han, Wei ;
Wang, Tao ;
Bedi, Kenneth ;
Morley, Michael P. ;
Saldana, Ricardo A. Linares ;
Bolar, Nikhita A. ;
McDaid, Kendra ;
Assenmacher, Charles-Antoine ;
Smith, Cheryl L. ;
Wirth, Dagmar ;
June, Carl H. ;
Margulies, Kenneth B. ;
Jain, Rajan ;
Pure, Ellen ;
Albelda, Steven M. ;
Epstein, Jonathan A. .
NATURE, 2019, 573 (7774) :430-+
[3]  
Agostini Carlo, 2006, Proc Am Thorac Soc, V3, P357, DOI 10.1513/pats.200601-010TK
[4]   Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease [J].
Arcasoy, SM ;
Christie, JD ;
Ferrari, VA ;
Sutton, MS ;
Zisman, DA ;
Blumenthal, NP ;
Pochettino, A ;
Kotloff, RM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (05) :735-740
[5]   Functional and structural impact of pirfenidone on the alterations of cardiac disease and diabetes mellitus [J].
Avila, Guillermo ;
Stephanie Osornio-Garduno, Diana ;
Benjamin Rios-Perez, Erick ;
Ramos-Mondragon, Roberto .
CELL CALCIUM, 2014, 56 (05) :428-435
[6]  
Basatemur GL, 2019, NAT REV CARDIOL, V16, P727, DOI [10.1038/s41569-019-0227-9, 10.1161/CIRCRESAHA.115.306361]
[7]   Diagnostic and Therapeutic Gaps in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease [J].
Canepa, Marco ;
Franssen, Frits M. E. ;
Olschewski, Horst ;
Lainscak, Mitja ;
Boehm, Michael ;
Tavazzi, Luigi ;
Rosenkranz, Stephan .
JACC-HEART FAILURE, 2019, 7 (10) :823-833
[8]   The Value of a Multidisciplinary Approach to the Diagnosis of Usual Interstitial Pneumonitis and Idiopathic Pulmonary Fibrosis: Radiology, Pathology, and Clinical Correlation [J].
Chung, Jonathan H. ;
Lynch, David A. .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2016, 206 (03) :463-471
[9]   Patient experiences with pulmonary fibrosis [J].
Collard, Harold R. ;
Tino, Gregory ;
Noble, Paul W. ;
Shreve, Mark A. ;
Michaels, Maureen ;
Carlson, Bruce ;
Schwarz, Marvin I. .
RESPIRATORY MEDICINE, 2007, 101 (06) :1350-1354
[10]   Treatment of Idiopathic Pulmonary Fibrosis with Losartan: A Pilot Project [J].
Couluris, Marisa ;
Kinder, Brent W. ;
Xu, Ping ;
Gross-King, Margaret ;
Krischer, Jeffrey ;
Panos, Ralph J. .
LUNG, 2012, 190 (05) :523-527
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