Molecular Landscape of ERBB2 Alterations in 14,956 Solid Tumors

被引：13

作者：

Wang, Hao ^{[1
]}

Miao, Ji ^{[1
]}

Wen, Yazhou ^{[2
]}

Xia, Xihua ^{[3
]}

Chen, Yanan ^{[3
]}

Huang, Mengli ^{[3
]}

Chen, Shiqing ^{[3
]}

Zhao, Zhengyi ^{[3
]}

Zhang, Yuzi ^{[3
]}

Chen, Chunzhu ^{[3
]}

Zhu, Xinhua ^{[1
]}

机构：

[1] Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Med Sch, Nanjing, Peoples R China

[2] Nanjing Med Univ, Womens Hosp, Nanjing Matern & Child Hlth Care Hosp, Dept Anesthesiol, Nanjing, Peoples R China

[3] 3D Med Inc, Med Dept, Shanghai, Peoples R China

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2022年 / 28卷

关键词：

next-generation sequencing; TMB; ERBB2; solid tumors; anti-HER2; agents; BREAST-CANCER; TRASTUZUMAB EMTANSINE; OPEN-LABEL; FAMILY;

D O I：

10.3389/pore.2022.1610360

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ERBB2 abnormalities frequently occur and serve as rationale therapeutic targets in cancer. In this study, clinical and next-generation sequencing data from 14,956 patients across more than 20 tumor types were collected. A total of 406 (2.7%) patients were identified with ERBB2 amplifications, and 303 (2.0%) patients with pathogenic somatic ERBB2 mutations. ERBB2 amplifications fell most frequently in breast (15.9%) and stomach (8.3%) cancers. Somatic ERBB2 SNVs/indels occurred most common in bladder/urinary tract (7.3%) and intestine (6.1%) cancers. The top mutated ERBB2 SNVs/indels were p.Y772_A775dup (25.5%) and p.S310F/Y (19.9%). Significantly higher rates of ERBB2 SNV/indels were found in women compared to men (2.8% vs. 1.5%, p < 0.0001). CDK12 was the most common co-amplification gene with ERBB2 in cancers with a high frequency of ERBB2 amplifications. Patients with ERBB2 amplifications or mutations had higher TMB compared with patients with non-ERBB2 alterations. The study provided the landscape of ERBB2 alterations across a variety of solid tumors that may benefit from anti-HER2 agents.

引用

页数：8

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