Ectopic fat: the true culprit linking obesity and cardiovascular disease?

被引：51
作者：
Morelli, Mariangela [1 ,2 ]
Gaggini, Melania [1 ,3 ]
Daniele, Giuseppe [4 ,5 ]
Marraccini, Paolo [1 ]
Sicari, Rosa [1 ]
Gastaldelli, Amalia [1 ,5 ]
机构：
[1] CNR, Inst Clin Physiol, I-56100 Pisa, Italy
[2] Univ Milan, Milan, Italy
[3] Univ Pisa, Dept Surg, I-56100 Pisa, Italy
[4] Univ Pisa, Dept Endocrinol & Metab, I-56100 Pisa, Italy
[5] Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, San Antonio, TX USA
来源：
THROMBOSIS AND HAEMOSTASIS | 2013年 / 110卷 / 04期
关键词：
SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2; DIABETES-MELLITUS; CORONARY-HEART-DISEASE; CARDIOMETABOLIC RISK-FACTORS; VISCERAL ABDOMINAL FAT; NECROSIS-FACTOR-ALPHA; LOW-CALORIE DIET; INSULIN-RESISTANCE; METABOLICALLY HEALTHY; BARIATRIC SURGERY;
D O I：
10.1160/TH13-04-0285
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity is a major risk factor for cardiovascular disease and its complications. However, not all fat depots share the same characteristics. Recent studies have found that ectopic rather than subcutaneous fat accumulation is associated with increased cardiometabolic risk. However, ectopic fat accumulation can be seen initially as a protective mechanism against lipotoxicity. Subsequently the adipose tissue becomes dysfunctional, thus inducing systemic metabolic alterations (through release of cytokines) or specific organ dysfunctions. The purpose of this review is to summarise the current available data on the impact of excess adiposity vs ectopic fat in the development of cardiometabolic diseases.
引用
收藏
页码：651 / 660
页数：10
相关论文
共 139 条
[1]   Relationship between obesity, insulin resistance, and coronary heart disease risk [J].
Abbasi, F ;
Brown, BW ;
Lamendola, C ;
McLaughlin, T ;
Reaven, GM .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (05) :937-943
[2]   Relationship of epicardial adipose tissue by echocardiography to coronary artery disease [J].
Ahn, S-G ;
Lim, H-S ;
Joe, D-Y ;
Kang, S-J ;
Choi, B-J ;
Choi, S-Y ;
Yoon, M-H ;
Hwang, G-S ;
Tahk, S-J ;
Shin, J-H .
HEART, 2008, 94 (03) :e7
[3]   Rasminogen activator inhibitor-1, adipose tissue and insulin resistance [J].
Alessi, Marie-Christine ;
Poggi, Marjorie ;
Juhan-Vague, Irene .
CURRENT OPINION IN LIPIDOLOGY, 2007, 18 (03) :240-245
[4]   Subcutaneous Adipose Tissue Remodeling during the Initial Phase of Weight Gain Induced by Overfeeding in Humans [J].
Alligier, M. ;
Meugnier, E. ;
Debard, C. ;
Lambert-Porcheron, S. ;
Chanseaume, E. ;
Sothier, M. ;
Loizon, E. ;
Hssain, A. Ait ;
Brozek, J. ;
Scoazec, J. -Y. ;
Morio, B. ;
Vidal, H. ;
Laville, M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (02) :E183-E192
[5]   Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents:: Race differential in diabetogenic and atherogenic risk factors [J].
Bacha, F ;
Saad, R ;
Gungor, N ;
Janosky, J ;
Arslanian, SA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) :2534-2540
[6]   Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men [J].
Banerji, MA ;
Faridi, N ;
Atluri, R ;
Chaiken, RL ;
Lebovitz, HE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (01) :137-144
[7]   Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat - Evidence of differences between visceral and subcutaneous deposits [J].
Bastelica, D ;
Morange, P ;
Berthet, B ;
Borghi, H ;
Lacroix, O ;
Grino, M ;
Juhan-Vague, I ;
Alessi, MC .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (01) :173-178
[8]   Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach [J].
Bays, H ;
Mandarino, L ;
DeFronzo, RA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (02) :463-478
[9]   Reductions in cardiovascular risk after bariatric surgery [J].
Benraouane, Fethi ;
Litwin, Sheldon E. .
CURRENT OPINION IN CARDIOLOGY, 2011, 26 (06) :555-561
[10]   Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? [J].
Bhatia, Lokpal S. ;
Curzen, Nicholas P. ;
Calder, Philip C. ;
Byrne, Christopher D. .
EUROPEAN HEART JOURNAL, 2012, 33 (10) :1190-+
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