Unfaithful association of FCGR2B genetic polymorphisms with susceptibility to SLE

被引:1
作者
Napolioni, Valerio [1 ]
Barucca, Alessandra [1 ]
Bolli, Elisabetta [1 ]
Concetti, Antonio [1 ]
Venanzi, Franco Maria [1 ]
机构
[1] Univ Camerino, Dept Biol MCA, I-62032 Camerino, Italy
关键词
Single nucleotide polymorphisms; FCGR2B; FCGR2C; homology; systemic lupus erythematosus; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GAMMA-RECEPTOR-IIB; CHINESE POPULATIONS; EXPRESSION; HAPLOTYPE;
D O I
10.1080/08916930802438782
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Correcting errors and proofreading are crucial in a post-genomic era, when DNA sequences are already part of an effective medical screening and treatments. SNPs genotyping of complex human genes can lead to questionable associations if not properly handled. Here, we report about a spurious (reitered) association between FCGR2B genetic polymorphisms and systemic lupus erythematosus.
引用
收藏
页码:139 / 142
页数:4
相关论文
共 13 条
  • [1] Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura
    Breunis, Willernijn B.
    van Mirre, Edwin
    Bruin, Marrie
    Geissler, Judy
    de Boer, Martin
    Peters, Marjolein
    Roos, Dirk
    de Haas, Masja
    Koene, Harry R.
    Kuijpers, Taco W.
    [J]. BLOOD, 2008, 111 (03) : 1029 - 1038
  • [2] Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
    Chen, Ji-Yih
    Wang, Chin Man
    Ma, Chung-Chun
    Luo, Shue-Fen
    Edberg, Jeffrey C.
    Kimberly, Robert P.
    Wu, Jianming
    [J]. ARTHRITIS AND RHEUMATISM, 2006, 54 (12): : 3908 - 3917
  • [3] Assessing the impact of population stratification on genetic association studies
    Freedman, ML
    Reich, D
    Penney, KL
    McDonald, GJ
    Mignault, AA
    Patterson, N
    Gabriel, SB
    Topol, EJ
    Smoller, JW
    Pato, CN
    Pato, MT
    Petryshen, TYL
    Kolonel, LN
    Lander, ES
    Sklar, P
    Henderson, B
    Hirschhorn, JN
    Altshuler, D
    [J]. NATURE GENETICS, 2004, 36 (04) : 388 - 393
  • [4] Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcγRIIC gene
    Metes, D
    Ernst, LK
    Chambers, WH
    Sulica, A
    Herberman, RB
    Morel, PA
    [J]. BLOOD, 1998, 91 (07) : 2369 - 2380
  • [5] Genetic susceptibility and haplotype analysis between Fcγ receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population
    Pan, F.
    Tang, X.
    Zhang, K.
    Li, X.
    Xu, J.
    Chen, H.
    Ye, D. Q.
    [J]. LUPUS, 2008, 17 (08) : 733 - 738
  • [6] RETRACTED: Gln50Ter Polymorphism of Fcγ receptor IIB gene associated with genetic susceptibility to human systemic lupus erythematosus in Chinese populations (Retracted Article. See vol 303, pg 67, 2011)
    Pan, Faming
    Ye, Dongqing
    Zhang, Kechun
    Li, Xiangpei
    Xu, Jianhua
    Chen, Hong
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2007, 299 (01) : 47 - 51
  • [7] Association of Fcγ receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations -: A family-based association study
    Pan, Faming
    Zhang, Kechun
    Li, Xiangpei
    Xu, Jianhua
    Hao, Jiahu
    Ye, Dongqing
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2006, 43 (01) : 35 - 41
  • [8] Inhibitory Fc gamma receptors: From gene to disease
    Stefanescu, RN
    Olferiev, M
    Liu, Y
    Pricop, L
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2004, 24 (04) : 315 - 326
  • [9] Genomic organization of classical human low-affinity Fcγ receptor genes
    Su, K
    Wu, J
    Edberg, JC
    McKenzie, SE
    Kimberly, RP
    [J]. GENES AND IMMUNITY, 2002, 3 (Suppl 1) : S51 - S56
  • [10] A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity.: I.: Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus
    Su, KH
    Wu, JM
    Edberg, JC
    Li, XL
    Ferguson, P
    Cooper, GS
    Langefeld, CD
    Kimberly, RP
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (11) : 7186 - 7191