Brain arteriolosclerosis

被引：113

作者：

Blevins, Brittney L. ^{[1
]}

Vinters, Harry V. ^{[2
,3
]}

Love, Seth ^{[4
,5
]}

Wilcock, Donna M. ^{[6
]}

Grinberg, Lea T. ^{[7
,23
,24
]}

Schneider, Julie A. ^{[8
,9
]}

Kalaria, Rajesh N. ^{[10
]}

Katsumata, Yuriko ^{[11
]}

Gold, Brian T. ^{[6
]}

Wang, Danny J. J. ^{[12
]}

Ma, Samantha J. ^{[12
]}

Shade, Lincoln M. P. ^{[11
]}

Fardo, David W. ^{[11
]}

Hartz, Anika M. S. ^{[13
]}

Jicha, Gregory A. ^{[14
]}

Nelson, Karin B. ^{[15
]}

Magaki, Shino D. ^{[2
,3
]}

Schmitt, Frederick A. ^{[14
]}

Teylan, Merilee A. ^{[16
]}

Ighodaro, Eseosa T. ^{[17
]}

Phe, Panhavuth ^{[18
]}

Abner, Erin L. ^{[19
]}

Cykowski, Matthew D. ^{[20
,21
]}

Van Eldik, Linda J. ^{[6
]}

Nelson, Peter T. ^{[22
,25
]}

机构：

[1] Univ Kentucky, Dept Neurosci, Lexington, KY 40536 USA

[2] UCLA, David Geffen SOM, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[3] Ronald Reagan UCLA Med Ctr, Los Angeles, CA 90095 USA

[4] Univ Bristol, Bristol BS10 5NB, Avon, England

[5] Southmead Hosp, Bristol BS10 5NB, Avon, England

[6] Univ Kentucky, Dept Neurosci, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[7] UCSF, Dept Neurol & Pathol, San Francisco, CA USA

[8] Rush Univ, Med Ctr, Dept Neurol, Chicago, IL 60612 USA

[9] Rush Univ, Med Ctr, Dept Pathol, Chicago, IL 60612 USA

[10] Newcastle Univ, Translat & Clin Res Inst, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[11] Univ Kentucky, Dept Biostat, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[12] Univ Southern Calif, Lab FMRI Technol LOFT, USC Mark & Mary Stevens Neuroimaging & Informat I, Keck Sch Med, Los Angeles, CA 90007 USA

[13] Univ Kentucky, Dept Pharmacol & Nutr Sci, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[14] Univ Kentucky, Dept Neurol, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[15] NIH, Bldg 10, Bethesda, MD 20892 USA

[16] Univ Washington, Dept Epidemiol, Seattle, WA 98105 USA

[17] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[18] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[19] Univ Kentucky, Dept Epidemiol, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[20] Houston Methodist Hosp, Dept Pathol, Houston, TX 77030 USA

[21] Houston Methodist Hosp, Dept Genom Med & Neurol, Houston, TX 77030 USA

[22] Univ Kentucky, Dept Pathol, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[23] UCSF, Global Brain Hlth Inst, San Francisco, CA USA

[24] Univ Sao Paulo, Sch Med, Dept Pathol, LIM 22, Sao Paulo, Brazil

[25] Univ Kentucky, Sanders Brown Ctr Aging, Rm 311,800 S Limestone Ave, Lexington, KY 40536 USA

来源：

ACTA NEUROPATHOLOGICA | 2021年 / 141卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

SVD; Arteriosclerosis; cAVU; Senescence; Neuropathology; Neuroimaging; SMALL-VESSEL DISEASE; VASCULAR COGNITIVE IMPAIRMENT; WHITE-MATTER HYPERINTENSITIES; GENOME-WIDE ASSOCIATION; CEREBRAL AMYLOID ANGIOPATHY; LACUNAR ISCHEMIC-STROKE; ALZHEIMERS-DISEASE; HIPPOCAMPAL SCLEROSIS; CEREBROVASCULAR PATHOLOGY; RETINAL VASCULOPATHY;

D O I：

10.1007/s00401-020-02235-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Here, we describe aspects of the unique architecture of brain arterioles, histomorphologic features of B-ASC, relevant neuroimaging findings, epidemiology and association with aging, established genetic risk factors, and the co-occurrence of B-ASC with other neuropathologic conditions such as Alzheimer's disease and limbic-predominant age-related TDP-43 encephalopathy (LATE). There may also be complex physiologic interactions between metabolic syndrome (e.g., hypertension and inflammation) and brain arteriolar pathology. Although there is no universally applied diagnostic methodology, several classification schemes and neuroimaging techniques are used to diagnose and categorize cerebral small vessel disease pathologies that include B-ASC, microinfarcts, microbleeds, lacunar infarcts, and cerebral amyloid angiopathy (CAA). In clinical-pathologic studies that factored in comorbid diseases, B-ASC was independently associated with impairments of global cognition, episodic memory, working memory, and perceptual speed, and has been linked to autonomic dysfunction and motor symptoms including parkinsonism. We conclude by discussing critical knowledge gaps related to B-ASC and suggest that there are probably subcategories of B-ASC that differ in pathogenesis. Observed in over 80% of autopsied individuals beyond 80 years of age, B-ASC is a complex and under-studied contributor to neurologic disability.

引用

页码：1 / 24

页数：24

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