Biological Macrocycle: Supramolecular Hydrophobic Guest Transport System Based on Nanodiscs with Photodynamic Activity

被引：6

作者：

Ge, Yan ^{[1
]}

Shen, Xin ^{[1
]}

Cao, Hongqian ^{[2
,4
]}

Jin, Lin ^{[1
]}

Shang, Jie ^{[1
]}

Wang, Yangxin ^{[1
]}

Pan, Tiezheng ^{[1
]}

Yang, Yang ^{[2
]}

Qi, Zhenhui ^{[1
,3
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Sino German Joint Res Lab Space Biomat & Translat, Xian 710072, Shaanxi, Peoples R China

[2] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Northwestern Polytech Univ, IBME, Xian 710072, Shaanxi, Peoples R China

[4] Shandong Univ, Dept Publ Hlth, Jinan 250012, Shandong, Peoples R China

来源：

LANGMUIR | 2019年 / 35卷 / 24期

基金：

中国博士后科学基金;

关键词：

MOLECULAR RECOGNITION; POLYMER; DERIVATIVES; CHAIN;

D O I：

10.1021/acs.langmuir.9b00126

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biogenic macrocycle-based guest loading system has been developed by the self-assembly of membrane scaffold protein and phospholipids. The resulting 10 nm level transport system can increase the solubility of hydrophobic photodynamic agent hypocrellin B in aqueous medium and exhibited a cellular internalization capacity with substantial photodynamic activity.

引用

页码：7824 / 7829

页数：6

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