Role of thyroid dysimmunity and thyroid hormones in endometriosis

被引：21

作者：

Peyneau, Marine ^{[1
]}

Kavian, Niloufar ^{[1
,2
,3
,4
]}

Chouzenoux, Sandrine ^{[1
]}

Nicco, Carole ^{[1
]}

Jeljeli, Mohamed ^{[1
,2
,3
]}

Toullec, Laurie ^{[1
]}

Reboul-Marty, Jeanne ^{[2
,5
]}

Chenevier-Gobeaux, Camille ^{[2
,6
]}

Reis, Fernando M. ^{[1
]}

Santulli, Pietro ^{[1
,2
,7
]}

Doridot, Ludivine ^{[1
]}

Chapron, Charles ^{[1
,2
,7
]}

Batteux, Frederic ^{[1
,2
,3
]}

机构：

[1] Univ Paris 05, Sorbonne Paris Cite, INSERM, Inst Cochin,U1016, F-75679 Paris, France

[2] Ctr Hosp Univ Cochin, AP HP, Hop Univ Paris Ctr, F-75679 Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, Serv Immunol Biol, F-75679 Paris, France

[4] Univ Hong Kong, Sch Publ Hlth, HKU Pasteur Res Pole, Hong Kong, Peoples R China

[5] Univ Paris 05, Sorbonne Paris Cite, Dept Informat Med, F-75679 Paris, France

[6] Univ Paris 05, Sorbonne Paris Cite, Serv Diagnost Biol Automatise, F-75679 Paris, France

[7] Univ Paris 05, Sorbonne Paris Cite, Dept Gynecol Obstet 2 & Med Reprod, F-75679 Paris, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2019年 / 116卷 / 24期

关键词：

thyroid; thyroid hormones; endometriosis; oxidative stress; autoimmunity; ACTIVATED PROTEIN-KINASE; STIMULATING HORMONE; INFILTRATING ENDOMETRIOSIS; CELL-PROLIFERATION; RECEPTORS; DISEASE; PATHOPHYSIOLOGY; AUTOIMMUNITY; PATHOGENESIS; INFERTILITY;

D O I：

10.1073/pnas.1820469116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium to triiodothyronine (T3) action and local accumulation of thyroxine (T4). Thyroid-stimulating hormone (TSH) acts as a proliferative and prooxidative hormone on all endometria of endometriosis patients and controls, whereas T3 and T4 act to specifically increase ectopic endometrial cell proliferation and reactive oxygen species (ROS) production. Mouse studies confirmed the data gained in vitro since endometriotic implants were found to be bigger when thyroid hormones increased. A retrospective analysis of endometriosis patients with or without a thyroid disorder revealed an increased chronic pelvic pain and disease score in endometriotic patients with a thyroid disorder.

引用

页码：11894 / 11899

页数：6

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