Visible-light-induced C(sp3)-H activation for a C-C bond forming reaction of 3,4-dihydroquinoxalin-2(1H)-one with nucleophiles using oxygen with a photoredox catalyst or under catalyst-free conditions

被引：27

作者：

Akula, Pavan Sudheer ^{[1
]}

Hong, Bor-Cherng ^{[1
]}

Lee, Gene-Hsiang ^{[2
]}

机构：

[1] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 621, Taiwan

[2] Natl Taiwan Univ, Instrumentat Ctr, Taipei 106, Taiwan

来源：

RSC ADVANCES | 2018年 / 8卷 / 35期

关键词：

MOLECULAR-OXYGEN; MULTICOMPONENT CASCADE; OXIDATIVE FORMYLATION; N-HETEROCYCLES; QUINOXALIN-2(1H)-ONES; ALKYLATION; ARYLATION; INDOLES; WATER; ACIDS;

D O I：

10.1039/c8ra03259a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient photocatalyzed oxidative coupling reaction of 4-alkyl-3,4-dihydroquinoxalin-2(1H)-one and its derivatives with a variety of nucleophiles was developed with a ruthenium photoredox catalyst and oxygen under a household compact fluorescent light. With a slower reaction rate, the cross coupling transformation can be achieved in the absence of an external photocatalyst with a similar isolated yield. An application to the synthesis of natural product cephalandole A was also demonstrated.

引用

收藏

页码：19580 / 19584

页数：5

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