Midlife aerobic exercise and brain structural integrity: Associations with age and cardiorespiratory fitness

被引：40

作者：

Tarumi, Takashi ^{[1
,2
,3
]}

Tomoto, Tsubasa ^{[1
]}

Repshas, Justin ^{[1
]}

Wang, Ciwen ^{[1
]}

Hynan, Linda S. ^{[4
,5
]}

Cullum, C. Munro ^{[2
,4
]}

Zhu, David C. ^{[6
,7
]}

Zhang, Rong ^{[1
,2
,8
]}

机构：

[1] Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Neurol, Dallas, TX USA

[3] Natl Inst Adv Ind Sci & Technol, Human Informat & Interact Res Inst, Tsukuba, Ibaraki, Japan

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX USA

[5] Univ Texas Southwestern Med Ctr Dallas, Dept Populat & Data Sci, Dallas, TX 75390 USA

[6] Michigan State Univ, Dept Radiol, 220 Trowbridge Rd, E Lansing, MI 48824 USA

[7] Michigan State Univ, Cognit Imaging Res Ctr, 220 Trowbridge Rd, E Lansing, MI 48824 USA

[8] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA

来源：

NEUROIMAGE | 2021年 / 225卷

基金：

美国国家卫生研究院;

关键词：

Midlife; Aerobic exercise; Brain volume; Cortical thickness; White matter integrity; Cardiorespiratory fitness; WHITE-MATTER INTEGRITY; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; NIH TOOLBOX; HIPPOCAMPAL VOLUME; CORTICAL THICKNESS; COGNITION BATTERY; DEMENTIA; OLDER; RELIABILITY;

D O I：

10.1016/j.neuroimage.2020.117512

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lower midlife physical activity is associated with higher risk of neurodegenerative disease in late life. However, it remains unknown whether physical exercise and fitness are associated with brain structural integrity during midlife. The purpose of this study was to compare brain structures between middle-aged aerobically trained adults (MA), middle-aged sedentary (MS), and young sedentary (YS) adults. Thirty MA (54 +/- 4 years), 30 MS (54 +/- 4 years), and 30 YS (32 +/- 6 years) participants (50% women) underwent measurements of brain volume, cortical thickness, and white matter (WM) fiber integrity using MRI. MA participants had aerobic training for 24.8 +/- 9.6 years and the highest cardiorespiratory fitness level (i.e., peak oxygen uptake: VO2peak) among all groups. Global WM integrity, as assessed with fractional anisotropy (FA) from diffusion tensor imaging, was lower in the MS compared with the YS group. However, global FA in the MA group was significantly higher than that in the MS group (P<0.05) and at a similar level to the YS group. Furthermore, tract-based spatial statistical analysis demonstrated that FA in the anterior, superior, and limbic WM tracts (e.g., the genu of the corpus callosum, superior longitudinal fasciculus, uncinate fasciculus) was higher in the MA compared with MS groups, and positively associated with VO2peak, independently from age and sex. From cortical thickness analysis, MS and MA participants showed thinner prefrontal and parieto-temporal areas than the YS group. On the other hand, the MA group exhibited thicker precentral, postcentral, pericalcarine, and lateral occipital cortices than the MS and YS groups. But, the insula and right superior frontal gyrus showed thinner cortical thickness in the MA compared with the MS groups. Collectively, these findings suggest that midlife aerobic exercise is associated with higher WM integrity and greater primary motor and somatosensory cortical thickness.

引用

页数：11

共 77 条

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