New secondary metabolites from the mangrove endophytic fungus Aspergillus versicolor

被引：20
作者：
Elsbaey, Marva [1 ,2 ]
Tanaka, Chiaki [2 ]
Miyamoto, Tomofumi [2 ]
机构：
[1] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt
[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Nat Prod Chem, Fukuoka, Fukuoka 8128582, Japan
来源：
PHYTOCHEMISTRY LETTERS | 2019年 / 32卷
关键词：
AsPergillus; Indoloditerpene; Meroterpenes; Endophyte; Stereochemistry; A-F; SESQUITERPENOIDS;
D O I：
10.1016/j.phytol.2019.04.023
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new oxoindolo diterpene epimers, anthcolorin G 1 and anthcolorin H 2, nine new meroterpenes, (7R,8R)-8-hydroxysydowic acid 4, (7S,10S)-10-hydroxy-sydowic acid 5, (7S,11R)-12-hydroxy-sydowic acid 6, (7S,11R)-12-acetoxy-sydowic acid 7, (7R,8R)-1,8-epoxy-11-hydroxy-sydonic acid 9, 7-deoxy-7,14-didehydro-11-hydroxy-sydonic acid 11, 7-deoxy-7,14-didehydro-12-acetoxy-sydonic acid 14, and (E)-7-deoxy-7,8-didehydro-12-acetoxy-sydonic acid 15, (7R)-11-hydroxy-sydonic acid methyl ester 18, and a benzoic acid derivative, isolated for the first time from a natural source, 3-hydroxy-4-(1-oxo-ethane) benzoic acid 10, in addition to twelve known compounds were isolated from the solid rice culture of the endophytic fungus Aspergillus versicolor. Their structures were determined by one- and two-dimensional NMR spectroscopy, high resolution electrospray ionization mass and circular dichroism spectra. Their cytotoxic activity was evaluated using Hela cells.
引用
收藏
页码：70 / 76
页数：7
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