Oxytocin Receptor Gene (OXTR) and Childhood Adversity Influence Trust

被引：18

作者：

Zheng, Shaofeng ^{[1
]}

Masuda, Takahiko ^{[2
]}

Matsunaga, Masahiro ^{[3
]}

Noguchi, Yasuki ^{[4
]}

Ohtsubo, Yohsuke ^{[4
]}

Yamasue, Hidenori ^{[5
]}

Ishii, Keiko ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Informat, Dept Cognit & Psychol Sci, Nagoya, Aichi, Japan

[2] Univ Alberta, Dept Psychol, Edmonton, AB, Canada

[3] Aichi Med Univ, Dept Hlth & Psychosocial Med, Nagakute, Aichi, Japan

[4] Kobe Univ, Grad Sch Humanities, Dept Psychol, Kobe, Hyogo, Japan

[5] Hamamatsu Univ Sch Med, Dept Psychiat, Hamamatsu, Shizuoka, Japan

来源：

PSYCHONEUROENDOCRINOLOGY | 2020年 / 121卷

关键词：

OXTR rs53576; childhood adversity; general trust; caution; DIFFERENTIAL SUSCEPTIBILITY; MATERNAL DEPRESSION; FAMILY ENVIRONMENT; SOCIAL SUPPORT; UNITED-STATES; POLYMORPHISM; STRESS; MODERATION; LIFE; MALTREATMENT;

D O I：

10.1016/j.psyneuen.2020.104840

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early-life environments have been associated with various social behaviors, including trust, in late adolescence and adulthood. Given that the oxytocin receptor gene polymorphism (OXTR rs53576) moderates the impact of childhood experience on social behaviors, in the present study, we examined the main effect of childhood adversity through a self-report measure and its interactions with OXTR rs53576 on general trust among 203 Japanese and 200 European Canadian undergraduate students. After controlling for the effect of culture, the results indicated that childhood adversity had a negative association with general trust, and that OXTR rs53576 moderated the impact of childhood adversity on general trust. Specifically, the negative association between childhood adversity and general trust is only significant among homozygote A-allele carriers. These findings demonstrated that OXTR rs53576 moderated the relations between childhood experiences and social functioning in early adulthood.

引用

页数：7

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